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De novo design and engineering of non-ribosomal peptide synthetases.
Nat Chem. 2018 Mar;10(3):275-281
Bozhüyük KAJ, Fleischhacker F, Linck A, Wesche F, Tietze A, Niesert CP, Bode HB
Metabolomics-based chemotaxonomy of root endophytic fungi for natural products discovery.
Environ Microbiol. 2018 Feb 14;:
Maciá-Vicente JG, Shi YN, Cheikh-Ali Z, Grün P, Glynou K, Haghi Kia S, Piepenbring M, Bode HB
Fully Anisotropic Rotational Diffusion Tensor from Molecular Dynamics Simulations.
J Phys Chem B. 2018 Feb 20;:
Linke M, Köfinger J, Hummer G
Chemical language and warfare of bacterial natural products in bacteria-nematode-insect interactions.
Nat Prod Rep. 2018 Jan 23;:
Shi YM, Bode HB
Engineering of hydroxymandelate synthases and the aromatic amino acid pathway enables de novo biosynthesis of mandelic and 4-hydroxymandelic acid with Saccharomyces cerevisiae.
Metab Eng. 2018 Jan;45:246-254
Reifenrath M, Boles E
Characterization of the Polyspecific Transferase of Murine Type I Fatty Acid Synthase (FAS) and Implications for Polyketide Synthase (PKS) Engineering.
ACS Chem Biol. 2018 Feb 01;:
Rittner A, Paithankar KS, Huu KV, Grininger M
High titer oncolytic measles virus production process by integration of dielectric spectroscopy as online monitoring system.
Biotechnol Bioeng. 2017 Dec 30;:
Grein TA, Loewe D, Dieken H, Salzig D, Weidner T, Czermak P
Molecular Basis for Converting (2S)-Methylsuccinyl-CoA Dehydrogenase into an Oxidase.
Molecules. 2017 Dec 28;23(1):
Burgener S, Schwander T, Romero E, Fraaije MW, Erb TJ
Structural basis for substrate specificity of methylsuccinyl-CoA dehydrogenase, an unusual member of the acyl-CoA dehydrogenase family.
J Biol Chem. 2018 Feb 02;293(5):1702-1712
Schwander T, McLean R, Zarzycki J, Erb TJ
Structural basis of proton translocation and force generation in mitochondrial ATP synthase.
Elife. 2017 12 06;6:
Klusch N, Murphy BJ, Mills DJ, Yildiz Ö, Kühlbrandt W
Optimisation of trans-cinnamic acid and hydrocinnamyl alcohol production with recombinant Saccharomyces cerevisiae and identification of cinnamyl methyl ketone as a by-product.
FEMS Yeast Res. 2017 Dec 01;17(8):
Gottardi M, Grün P, Bode HB, Hoffmann T, Schwab W, Oreb M, Boles E
Reassessment of inclusion body-based production as a versatile opportunity for difficult-to-express recombinant proteins.
Crit Rev Biotechnol. 2017 Nov 10;:1-16
Hoffmann D, Ebrahimi M, Gerlach D, Salzig D, Czermak P
Classical Molecular Dynamics with Mobile Protons.
Scaffolding the cup-shaped double membrane in autophagy.
PLoS Comput Biol. 2017 Oct;13(10):e1005817
Bahrami AH, Lin MG, Ren X, Hurley JH, Hummer G
Dynamic Histogram Analysis To Determine Free Energies and Rates from Biased Simulations.
J Chem Theory Comput. 2017 Dec 12;13(12):6328-6342
Stelzl LS, Kells A, Rosta E, Hummer G
Transition path sampling of rare events by shooting from the top.
J Chem Phys. 2017 Oct 21;147(15):152716
Jung H, Okazaki KI, Hummer G
Insights into Cotranslational Membrane Protein Insertion by Combined LILBID-Mass Spectrometry and NMR Spectroscopy.
Anal Chem. 2017 Nov 21;89(22):12314-12318
Peetz O, Henrich E, Laguerre A, Löhr F, Hein C, Dötsch V, Bernhard F, Morgner N
NMR experiments for the rapid identification of P=O···H-X type hydrogen bonds in nucleic acids.
J Biomol NMR. 2017 Oct;69(2):101-110
Duchardt-Ferner E, Wöhnert J
Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus.
Nat Microbiol. 2017 Dec;2(12):1676-1685
Tobias NJ, Wolff H, Djahanschiri B, Grundmann F, Kronenwerth M, Shi YM, Simonyi S, Grün P, Shapiro-Ilan D, Pidot SJ, Stinear TP, Ebersberger I, Bode HB
Biosynthesis and function of simple amides in Xenorhabdus doucetiae.
Environ Microbiol. 2017 Nov;19(11):4564-4575
Bode E, He Y, Vo TD, Schultz R, Kaiser M, Bode HB
Formation and Stability of Lipid Membrane Nanotubes.
Non-invasive Raman Spectroscopy and Quantitative Real-Time PCR Distinguish Among Undifferentiated Human Mesenchymal Stem Cells and Redifferentiated Nucleus Pulposus Cells and Chondrocytes In Vitro.
Open Biomed Eng J. 2017;11:72-84
Ehlicke F, Köster N, Salzig D, Czermak P
Nicotinamide Adenine Dinucleotides Arrest Photoreduction of Class II DNA Photolyases in FADH˙ State.
Photochem Photobiol. 2018 Jan;94(1):81-87
Ignatz E, Geisselbrecht Y, Kiontke S, Essen LO
Baculovirus-induced recombinant protein expression in human mesenchymal stromal stem cells: A promoter study.
N Biotechnol. 2017 Oct 25;39(Pt B):161-166
Sprick G, Weidner T, Salzig D, Czermak P
The components of shear stress affecting insect cells used with the baculovirus expression vector system.
Z Naturforsch C. 2017 Sep 26;72(9-10):429-439
Weidner T, Druzinec D, Mühlmann M, Buchholz R, Czermak P
Cryo-EM Structure of the TOM Core Complex from Neurospora crassa.
Cell. 2017 Aug 10;170(4):693-700.e7
Bausewein T, Mills DJ, Langer JD, Nitschke B, Nussberger S, Kühlbrandt W
Resolving the Conformational Dynamics of DNA with Ångstrom Resolution by Pulsed Electron-Electron Double Resonance and Molecular Dynamics.
J Am Chem Soc. 2017 Aug 30;139(34):11674-11677
Stelzl LS, Erlenbach N, Heinz M, Prisner TF, Hummer G
Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila.
Elife. 2017 Jul 12;6:
Brandt T, Mourier A, Tain LS, Partridge L, Larsson NG, Kühlbrandt W
Strategies in megasynthase engineering - fatty acid synthases (FAS) as model proteins.
Structural characterization of the NAP; the major adhesion complex of the human pathogen Mycoplasma genitalium.
Mol Microbiol. 2017 Sep;105(6):869-879
Scheffer MP, Gonzalez-Gonzalez L, Seybert A, Ratera M, Kunz M, Valpuesta JM, Fita I, Querol E, Piñol J, Martín-Benito J, Frangakis AS
LuxS-dependent AI-2 production is not involved in global regulation of natural product biosynthesis in Photorhabdus and Xenorhabdus.
PeerJ. 2017;5:e3471
Heinrich AK, Hirschmann M, Neubacher N, Bode HB
Kinetics from Replica Exchange Molecular Dynamics Simulations.
Identification and occurrence of the hydroxamate siderophores aerobactin, putrebactin, avaroferrin and ochrobactin C as virulence factors from entomopathogenic bacteria.
Environ Microbiol. 2017 Oct;19(10):4080-4090
Hirschmann M, Grundmann F, Bode HB
Structure and in situ organisation of the Pyrococcus furiosus archaellum machinery.
Elife. 2017 Jun 27;6:
Daum B, Vonck J, Bellack A, Chaudhury P, Reichelt R, Albers SV, Rachel R, Kühlbrandt W
Secretion of 2,3-dihydroxyisovalerate as a limiting factor for isobutanol production in Saccharomyces cerevisiae.
FEMS Yeast Res. 2017 May 01;17(3):
Generoso WC, Brinek M, Dietz H, Oreb M, Boles E
A conserved threonine prevents self-intoxication of enoyl-thioester reductases.
Nat Chem Biol. 2017 Jul;13(7):745-749
Rosenthal RG, Vögeli B, Wagner T, Shima S, Erb TJ
Position-Dependent Diffusion Tensors in Anisotropic Media from Simulation: Oxygen Transport in and through Membranes.
J Chem Theory Comput. 2017 Jun 13;13(6):2962-2976
Ghysels A, Venable RM, Pastor RW, Hummer G
Anaerobic Membrane Bioreactor for Continuous Lactic Acid Fermentation.
Membranes (Basel). 2017 May 03;7(2):
Fan R, Ebrahimi M, Czermak P
Microbiology: A new language for small talk.
Solid-phase enrichment and analysis of electrophilic natural products.
Beilstein J Org Chem. 2017;13:405-409
Wesche F, He Y, Bode HB
Structure and Biosynthesis of Isatropolones, Bioactive Amine-Scavenging Fluorescent Natural Products from Streptomyces Gö66.
Angew Chem Int Ed Engl. 2017 Apr 24;56(18):4945-4949
Cai X, Shi YM, Pöhlmann N, Revermann O, Bahner I, Pidot SJ, Wesche F, Lackner H, Büchel C, Kaiser M, Richter C, Schwalbe H, Stinear TP, Zeeck A, Bode HB
De novo biosynthesis of trans-cinnamic acid derivatives in Saccharomyces cerevisiae.
Appl Microbiol Biotechnol. 2017 Jun;101(12):4883-4893
Gottardi M, Knudsen JD, Prado L, Oreb M, Branduardi P, Boles E
Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design.
Nat Chem. 2017 Apr;9(4):379-386
Cai X, Nowak S, Wesche F, Bischoff I, Kaiser M, Fürst R, Bode HB
Engineering fungal de novo fatty acid synthesis for short chain fatty acid production.
Nat Commun. 2017 Mar 10;8:14650
Gajewski J, Pavlovic R, Fischer M, Boles E, Grininger M
The Global Regulators Lrp, LeuO, and HexA Control Secondary Metabolism in Entomopathogenic Bacteria.
Front Microbiol. 2017;8:209
Engel Y, Windhorst C, Lu X, Goodrich-Blair H, Bode HB
Engineering fatty acid synthases for directed polyketide production.
Nat Chem Biol. 2017 04;13(4):363-365
Gajewski J, Buelens F, Serdjukow S, Janßen M, Cortina N, Grubmüller H, Grininger M
Expanding the product portfolio of fungal type I fatty acid synthases.
Nat Chem Biol. 2017 04;13(4):360-362
Zhu Z, Zhou YJ, Krivoruchko A, Grininger M, Zhao ZK, Nielsen J
A high-throughput expression screening platform to optimize the production of antimicrobial peptides.
Microb Cell Fact. 2017 Feb 13;16(1):29
Schreiber C, Müller H, Birrenbach O, Klein M, Heerd D, Weidner T, Salzig D, Czermak P
Biosynthesis of the Antibiotic Nematophin and Its Elongated Derivatives in Entomopathogenic Bacteria.
Org Lett. 2017 Feb 17;19(4):806-809
Cai X, Challinor VL, Zhao L, Reimer D, Adihou H, Grün P, Kaiser M, Bode HB
Optimized expression of the antimicrobial protein Gloverin from Galleria mellonella using stably transformed Drosophila melanogaster S2 cells.
Cytotechnology. 2017 Apr;69(2):371-389
Zitzmann J, Weidner T, Czermak P
Carbon Nanotubes Mediate Fusion of Lipid Vesicles.
ACS Nano. 2017 Feb 28;11(2):1273-1280
Bhaskara RM, Linker SM, Vögele M, Köfinger J, Hummer G
Natural Products from Photorhabdus and Other Entomopathogenic Bacteria.
Curr Top Microbiol Immunol. 2017;402:55-79
Bozhüyük KAJ, Zhou Q, Engel Y, Heinrich A, Pérez A, Bode HB
Analyzing native membrane protein assembly in nanodiscs by combined non-covalent mass spectrometry and synthetic biology.
Elife. 2017 Jan 09;6:
Henrich E, Peetz O, Hein C, Laguerre A, Hoffmann B, Hoffmann J, Dötsch V, Bernhard F, Morgner N
Screening different host cell lines for the dynamic production of measles virus.
Biotechnol Prog. 2017 Jul;33(4):989-997
Grein TA, Schwebel F, Kress M, Loewe D, Dieken H, Salzig D, Weidner T, Czermak P
A Stably Protonated Adenine Nucleotide with a Highly Shifted pKa Value Stabilizes the Tertiary Structure of a GTP-Binding RNA Aptamer.
Angew Chem Int Ed Engl. 2017 Jan 02;56(1):401-404
Wolter AC, Weickhmann AK, Nasiri AH, Hantke K, Ohlenschläger O, Wunderlich CH, Kreutz C, Duchardt-Ferner E, Wöhnert J
NMR resonance assignments for the tetramethylrhodamine binding RNA aptamer 3 in complex with the ligand 5-carboxy-tetramethylrhodamine.
Biomol NMR Assign. 2017 Apr;11(1):29-34
Duchardt-Ferner E, Juen M, Kreutz C, Wöhnert J
Photorhabdus-nematode symbiosis is dependent on hfq-mediated regulation of secondary metabolites.
Environ Microbiol. 2017 Jan;19(1):119-129
Tobias NJ, Heinrich AK, Eresmann H, Wright PR, Neubacher N, Backofen R, Bode HB
Three-dimensional CTF correction improves the resolution of electron tomograms.
Helical jackknives control the gates of the double-pore K+ uptake system KtrAB
Elife. 2017 May 16;6. pii: e24303
Diskowski M, Mehdipour AR, Wunnicke D, Mills DJ, Mikusevic V, Bärland N, Hoffmann J, Morgner N, Steinhoff HJ, Hummer G, Vonck J, Hänelt I
Advances in high-resolution cryo-EM of oligomeric enzymes

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