Publications



Arbeiten von MegaSyn Mitgliedern. MegaSyn Mitglieder sind korrespondiere Autoren.

Understanding Substrate Selectivity of Phoslactomycin Polyketide Synthase by Using Reconstituted in Vitro Systems
Chembiochem 2020 Mar 30
Geyer K, Sundaram S, Sušnik P, Koert U, Erb TJ
A New Docking Domain Type in the Peptide-Antimicrobial-Xenorhabdus Peptide Producing Nonribosomal Peptide Synthetase from Xenorhabdus bovienii
ACS Chem Biol 2020 Mar 25
Watzel J, Hacker C, Duchardt-Ferner E, Bode HB, Wöhnert J
The resolution revolution in cryoEM requires high-quality sample preparation: a rapid pipeline to a high-resolution map of yeast fatty acid synthase
IUCrJ 2020 Jan 25;7(Pt 2):220-227
Joppe M, D'Imprima E, Salustros N, Paithankar KS, Vonck J, Grininger M, Kühlbrandt W
Reply to Desikan et al
: Micelle formation among various mechanisms of toxin pore formation Proc Natl Acad Sci U S A
Vögele M, Bhaskara RM, Mulvihill E, van Pee K, Yildiz Ö, Kühlbrandt W, Müller DJ, Hummer G
Innovative Optical-Sensing Technology for the Online Fouling Characterization of Silicon Carbide Membranes during the Treatment of Oily Water
Sensors (Basel) 2020 Feb 20;20(4)
Ebrahimi M, Schmidt AA, Kaplan C, Schmitz O, Czermak P
Analysis of the co-translational assembly of the fungal fatty acid synthase (FAS)
Sci Rep 2020 Jan 21;10(1):895
Fischer M, Joppe M, Mulinacci B, Vollrath R, Konstantinidis K, Kötter P, Ciccarelli L, Vonck J, Oesterhelt D, Grininger M
Opportunities to debottleneck the downstream processing of the oncolytic measles virus
Crit Rev Biotechnol 2020 Mar;40(2):247-264
Loewe D, Dieken H, Grein TA, Weidner T, Salzig D, Czermak P
Oxalyl-CoA Decarboxylase Enables Nucleophilic One-Carbon Extension of Aldehydes to Chiral α-Hydroxy Acids
Identification of the 3-amino-3-carboxypropyl (acp) transferase enzyme responsible for acp3U formation at position 47 in Escherichia coli tRNAs
Nucleic Acids Res 2020 Feb 20;48(3):1435-1450
Meyer B, Immer C, Kaiser S, Sharma S, Yang J, Watzinger P, Weiß L, Kotter A, Helm M, Seitz HM, Kötter P, Kellner S, Entian KD, Wöhnert J
Turbidimetry and Dielectric Spectroscopy as Process Analytical Technologies for Mammalian and Insect Cell Cultures
Methods Mol Biol 2020;2095:335-364
Käßer L, Zitzmann J, Grein T, Weidner T, Salzig D, Czermak P
Ion Binding and Selectivity of the Na(+)/H(+) Antiporter MjNhaP1 from Experiment and Simulation
J Phys Chem B 2020 Jan 16;124(2):336-344
Warnau J, Wöhlert D, Okazaki KI, Yildiz Ö, Gamiz-Hernandez AP, Kaila VRI, Kühlbrandt W, Hummer G
Phototemtide A, a Cyclic Lipopeptide Heterologously Expressed from Photorhabdus temperata Meg1, Shows Selective Antiprotozoal Activity
Chembiochem 2019 Dec 9
Zhao L, Vo TD, Kaiser M, Bode HB
Type I fatty acid synthase trapped in the octanoyl-bound state
Protein Sci 2020 Feb;29(2):589-605
Rittner A, Paithankar KS, Himmler A, Grininger M
Hierarchical Ensembles of Intrinsically Disordered Proteins at Atomic Resolution in Molecular Dynamics Simulations
J Chem Theory Comput 2020 Jan 14;16(1):725-737
Pietrek LM, Stelzl LS, Hummer G
Crystal structure of the translation recovery factor Trf from Sulfolobus solfataricus
FEBS Open Bio 2019 Dec 5
Kaiser M, Wurm JP, Märtens B, Bläsi U, Pogoryelov D, Wöhnert J
Structure, Biosynthesis, and Bioactivity of Photoditritide from Photorhabdus temperata Meg1
J Nat Prod 2019 Dec 27;82(12):3499-3503
Zhao L, Awori RM, Kaiser M, Groß J, Opatz T, Bode HB
Tangential Flow Filtration for the Concentration of Oncolytic Measles Virus: The Influence of Filter Properties and the Cell Culture Medium
Membranes (Basel) 2019 Nov 29;9(12)
Loewe D, Grein TA, Dieken H, Weidner T, Salzig D, Czermak P
High-resolution EPR distance measurements on RNA and DNA with the non-covalent Ǵ spin label
Nucleic Acids Res 2020 Jan 24;48(2):924-933
Heinz M, Erlenbach N, Stelzl LS, Thierolf G, Kamble NR, Sigurdsson ST, Prisner TF, Hummer G
Structure of an RNA aptamer in complex with the fluorophore tetramethylrhodamine
Nucleic Acids Res 2020 Jan 24;48(2):949-961
Duchardt-Ferner E, Juen M, Bourgeois B, Madl T, Kreutz C, Ohlenschläger O, Wöhnert J
Revolutionizing agriculture with synthetic biology
Nat Plants 2019 Dec;5(12):1207-1210
Wurtzel ET, Vickers CE, Hanson AD, Millar AH, Cooper M, Voss-Fels KP, Nikel PI, Erb TJ
Marine Proteobacteria metabolize glycolate via the β-hydroxyaspartate cycle
Nature 2019 Nov;575(7783):500-504
Schada von Borzyskowski L, Severi F, Krüger K, Hermann L, Gilardet A, Sippel F, Pommerenke B, Claus P, Cortina NS, Glatter T, Zauner S, Zarzycki J, Fuchs BM, Bremer E, Maier UG, Amann RI, Erb TJ
Development and Characterization of an Enzyme Membrane Reactor for Fructo-Oligosaccharide Production
Membranes (Basel) 2019 Nov 10;9(11)
Burghardt JP, Coletta LA, van der Bolt R, Ebrahimi M, Gerlach D, Czermak P
Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing
Angew Chem Int Ed Engl 2019 Dec 19;58(52):18957-18963
Bode E, Heinrich AK, Hirschmann M, Abebew D, Shi YN, Vo TD, Wesche F, Shi YM, Grün P, Simonyi S, Keller N, Engel Y, Wenski S, Bennet R, Beyer S, Bischoff I, Buaya A, Brandt S, Cakmak I, Çimen H, Eckstein S, Frank D, Fürst R, Gand M, Geisslinger G, Hazir S, Henke M, Heermann R, Lecaudey V, Schäfer W, Schiffmann S, Schüffler A, Schwenk R, Skaljac M, Thines E, Thines M, Ulshöfer T, Vilcinskas A, Wichelhaus TA, Bode HB
Selection of High Producers From Combinatorial Libraries for the Production of Recombinant Proteins in Escherichia coli and Vibrio natriegens
Front Bioeng Biotechnol 2019 Oct 4;7:254
Eichmann J, Oberpaul M, Weidner T, Gerlach D, Czermak P
Design and Control of Extrachromosomal Elements in Methylorubrum extorquens AM1
ACS Synth Biol 2019 Nov 15;8(11):2451-2456
Carrillo M, Wagner M, Petit F, Dransfeld A, Becker A, Erb TJ
Phospholipid Scramblases Remodel the Shape of Asymmetric Membranes
J Phys Chem Lett 2019 Oct 17;10(20):6351-6354
Siggel M, Bhaskara RM, Hummer G
Structure of the archaeal chemotaxis protein CheY in a domain-swapped dimeric conformation
Acta Crystallogr F Struct Biol Commun 2019 Sep 1;75(Pt 9):576-585
Paithankar KS, Enderle M, Wirthensohn DC, Miller A, Schlesner M, Pfeiffer F, Rittner A, Grininger M, Oesterhelt D
NMR resonance assignments for the GSPII-B domain of the traffic ATPase PilF from Thermus thermophilus in the apo and the c-di-GMP-bound state
Biomol NMR Assign 2019 Oct;13(2):383-390
Neißner K, Keller H, Duchardt-Ferner E, Hacker C, Kruse K, Averhoff B, Wöhnert J
(±)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210 Isolated from the Halophyte Salicornia sp
J Org Chem 2019 Sep 6;84(17):11203-11209
Shi YN, Pusch S, Shi YM, Richter C, Maciá-Vicente JG, Schwalbe H, Kaiser M, Opatz T, Bode HB
Production of a photohexapeptide library from entomopathogenic Photorhabdus asymbiotica PB68
1 Org Biomol Chem
Zhao L, Bode HB
Inferring Structural Ensembles of Flexible and Dynamic Macromolecules Using Bayesian, Maximum Entropy, and Minimal-Ensemble Refinement Methods
Methods Mol Biol 2019;2022:341-352
Köfinger J, Różycki B, Hummer G
Forced Degradation Studies to Identify Critical Process Parameters for the Purification of Infectious Measles Virus
Viruses 2019 Aug 7;11(8)
Loewe D, Häussler J, Grein TA, Dieken H, Weidner T, Salzig D, Czermak P
NMR resonance assignments for the GSPII-C domain of the PilF ATPase from Thermus thermophilus in complex with c-di-GMP
Biomol NMR Assign 2019 Oct;13(2):361-366
Keller H, Kruse K, Averhoff B, Duchardt-Ferner E, Wöhnert J
Ultrafast Oxidation of a Tyrosine by Proton-Coupled Electron Transfer Promotes Light Activation of an Animal-like Cryptochrome
J Am Chem Soc 2019 Aug 28;141(34):13394-13409
Lacombat F, Espagne A, Dozova N, Plaza P, Müller P, Brettel K, Franz-Badur S, Essen LO
Molecular mechanism of polyketide shortening in anthraquinone biosynthesis of Photorhabdus luminescens
Chem Sci 2019 May 14;10(25):6341-6349
Zhou Q, Bräuer A, Adihou H, Schmalhofer M, Saura P, Grammbitter GLC, Kaila VRI, Groll M, Bode HB
Comparative biochemical and structural analysis of the flavin-binding dodecins from Streptomyces davaonensis and Streptomyces coelicolor reveals striking differences with regard to multimerization
Microbiology 2019 Oct;165(10):1095-1106
Bourdeaux F, Ludwig P, Paithankar K, Sander B, Essen LO, Grininger M, Mack M
Process Intensification for an Insect Antimicrobial Peptide Elastin-Like Polypeptide Fusion Produced in Redox-Engineered Escherichia coli
Front Bioeng Biotechnol 2019 Jun 27;7:150
Joachim M, Maguire N, Schäfer J, Gerlach D, Czermak P
Cryo-EM structure of Neurospora crassa respiratory complex IV
IUCrJ 2019 Jun 26;6(Pt 4):773-780
Bausewein T, Nussberger S, Kühlbrandt W
Improving isobutanol production with the yeast Saccharomyces cerevisiae by successively blocking competing metabolic pathways as well as ethanol and glycerol formation
Biotechnol Biofuels 2019 Jul 2;12:173
Wess J, Brinek M, Boles E
Structural changes within the bifunctional cryptochrome/photolyase CraCRY upon blue light excitation
Sci Rep 2019 Jul 9;9(1):9896
Franz-Badur S, Penner A, Straß S, von Horsten S, Linne U, Essen LO
Dynamic Metabolic Rewiring Enables Efficient Acetyl Coenzyme A Assimilation in Paracoccus denitrificans
mBio 2019 Jul 9;10(4)
Kremer K, van Teeseling MCF, Schada von Borzyskowski L, Bernhardsgrütter I, van Spanning RJM, Gates AJ, Remus-Emsermann MNP, Thanbichler M, Erb TJ
Four amino acids define the CO(2) binding pocket of enoyl-CoA carboxylases/reductases
Proc Natl Acad Sci U S A 2019 Jul 9;116(28):13964-13969
Stoffel GMM, Saez DA, DeMirci H, Vögeli B, Rao Y, Zarzycki J, Yoshikuni Y, Wakatsuki S, Vöhringer-Martinez E, Erb TJ
Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F(1)-F(o) coupling
Science 2019 Jun 21;364(6446)
Murphy BJ, Klusch N, Langer J, Mills DJ, Yildiz Ö, Kühlbrandt W
Membrane perforation by the pore-forming toxin pneumolysin
Proc Natl Acad Sci U S A 2019 Jul 2;116(27):13352-13357
Vögele M, Bhaskara RM, Mulvihill E, van Pee K, Yildiz Ö, Kühlbrandt W, Müller DJ, Hummer G
De novo production of aromatic m-cresol in Saccharomyces cerevisiae mediated by heterologous polyketide synthases combined with a 6-methylsalicylic acid decarboxylase
Awakening the Sleeping Carboxylase Function of Enzymes: Engineering the Natural CO(2)-Binding Potential of Reductases
J Am Chem Soc 2019 Jun 26;141(25):9778-9782
Bernhardsgrütter I, Schell K, Peter DM, Borjian F, Saez DA, Vöhringer-Martinez E, Erb TJ
Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains
Nat Chem 2019 Jul;11(7):653-661
Bozhüyük KAJ, Linck A, Tietze A, Kranz J, Wesche F, Nowak S, Fleischhacker F, Shi YN, Grün P, Bode HB
Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy
Nat Commun 2019 May 30;10(1):2370
Bhaskara RM, Grumati P, Garcia-Pardo J, Kalayil S, Covarrubias-Pinto A, Chen W, Kudryashev M, Dikic I, Hummer G
Finite-Size-Corrected Rotational Diffusion Coefficients of Membrane Proteins and Carbon Nanotubes from Molecular Dynamics Simulations
J Phys Chem B 2019 Jun 20;123(24):5099-5106
Vögele M, Köfinger J, Hummer G
Cyclo(tetrahydroxybutyrate) production is sufficient to distinguish between Xenorhabdus and Photorhabdus isolates in Thailand
Environ Microbiol 2019 Aug;21(8):2921-2932
Tobias NJ, Parra-Rojas C, Shi YN, Shi YM, Simonyi S, Thanwisai A, Vitta A, Chantratita N, Hernandez-Vargas EA, Bode HB
Heterogeneity in Bacterial Specialized Metabolism
(1)H, (13)C, (15)N backbone NMR resonance assignments for the rRNA methyltransferase Dim1 from the hyperthermophilic archaeon Pyrococcus horikoshii
Biomol NMR Assign 2019 Oct;13(2):309-314
Kaiser M, Hacker C, Duchardt-Ferner E, Wöhnert J
Aeration and Shear Stress Are Critical Process Parameters for the Production of Oncolytic Measles Virus
Front Bioeng Biotechnol 2019 Apr 17;7:78
Grein TA, Loewe D, Dieken H, Weidner T, Salzig D, Czermak P
Dynamic cluster formation determines viscosity and diffusion in dense protein solutions
Proc Natl Acad Sci U S A 2019 May 14;116(20):9843-9852
von Bülow S, Siggel M, Linke M, Hummer G
NMR resonance assignments for the GTP-binding RNA aptamer 9-12 in complex with GTP
Biomol NMR Assign 2019 Oct;13(2):281-286
Wolter AC, Pianu A, Kremser J, Strebitzer E, Schnieders R, Fürtig B, Kreutz C, Duchardt-Ferner E, Wöhnert J
Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting
Nat Commun 2019 Apr 15;10(1):1742
Okazaki KI, Wöhlert D, Warnau J, Jung H, Yildiz Ö, Kühlbrandt W, Hummer G
Efficient Ensemble Refinement by Reweighting
J Chem Theory Comput 2019 May 14;15(5):3390-3401
Köfinger J, Stelzl LS, Reuter K, Allande C, Reichel K, Hummer G
Protein denaturation at the air-water interface and how to prevent it
Elife 2019 Apr 1;8
D'Imprima E, Floris D, Joppe M, Sánchez R, Grininger M, Kühlbrandt W
Recovery of Lignosulfonates from Spent Sulfite Liquor Using Ceramic Hollow-Fiber Membranes
Membranes (Basel) 2019 Mar 28;9(4)
Humpert D, Ebrahimi M, Stroh A, Czermak P
Fatty Acid Biosynthesis: Chain-Length Regulation and Control
Chembiochem 2019 Sep 16;20(18):2298-2321
Heil CS, Wehrheim SS, Paithankar KS, Grininger M
An Uncommon Type II PKS Catalyzes Biosynthesis of Aryl Polyene Pigments
J Am Chem Soc 2019 Oct 23;141(42):16615-16623
Grammbitter GLC, Schmalhofer M, Karimi K, Shi YM, Schöner TA, Tobias NJ, Morgner N, Groll M, Bode HB
Structure and Mechanisms of F-Type ATP Synthases
Dual phenazine gene clusters enable diversification during biosynthesis
Nat Chem Biol 2019 Apr;15(4):331-339
Shi YM, Brachmann AO, Westphalen MA, Neubacher N, Tobias NJ, Bode HB
Back to the future: Why we need enzymology to build a synthetic metabolism of the future
Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila
Beilstein J Org Chem 2019 Feb 25;15:535-541
Wesche F, Adihou H, Wichelhaus TA, Bode HB
Reprogramming Promiscuous Nonribosomal Peptide Synthetases for Production of Specific Peptides
Org Lett 2019 Apr 5;21(7):2116-2120
Cai X, Zhao L, Bode HB
Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows
Proc Natl Acad Sci U S A 2019 Mar 5;116(10):4250-4255
Blum TB, Hahn A, Meier T, Davies KM, Kühlbrandt W
Respiratory supercomplexes III(2)IV(2) come into focus
Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains
ACS Chem Biol 2019 Mar 15;14(3):426-433
Klaus M, D'Souza AD, Nivina A, Khosla C, Grininger M
The structure of the SAM/SAH-binding riboswitch
Nucleic Acids Res 2019 Mar 18;47(5):2654-2665
Weickhmann AK, Keller H, Wurm JP, Strebitzer E, Juen MA, Kremser J, Weinberg Z, Kreutz C, Duchardt-Ferner E, Wöhnert J
Downstream processing of Cry4AaCter-induced inclusion bodies containing insect-derived antimicrobial peptides produced in Escherichia coli
Protein Expr Purif 2019 Mar;155:120-129
Hoffmann D, Eckhardt D, Gerlach D, Vilcinskas A, Czermak P
Editorial overview: Novel enzymes, coenzymes, and metabolic pathways
Native mass spectrometry goes more native: investigation of membrane protein complexes directly from SMALPs
Chem Commun (Camb) 2018 Dec 4;54(97):13702-13705
Hellwig N, Peetz O, Ahdash Z, Tascón I, Booth PJ, Mikusevic V, Diskowski M, Politis A, Hellmich Y, Hänelt I, Reading E, Morgner N
Structural and Functional Characterization of PA14/Flo5-Like Adhesins From Komagataella pastoris
Front Microbiol 2018 Oct 30;9:2581
Kock M, Brückner S, Wozniak N, Maestre-Reyna M, Veelders M, Schlereth J, Mösch HU, Essen LO
Probing the modularity of megasynthases by rational engineering of a fatty acid synthase Type I
Protein Sci 2019 Feb;28(2):414-428
Rittner A, Paithankar KS, Drexler DJ, Himmler A, Grininger M
The multicatalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite
Nat Chem Biol 2018 Dec;14(12):1127-1132
Bernhardsgrütter I, Vögeli B, Wagner T, Peter DM, Cortina NS, Kahnt J, Bange G, Engilberge S, Girard E, Riobé F, Maury O, Shima S, Zarzycki J, Erb TJ
Bacterial bifunctional chorismate mutase-prephenate dehydratase PheA increases flux into the yeast phenylalanine pathway and improves mandelic acid production
Metab Eng Commun 2018 Sep 22;7:e00079
Reifenrath M, Bauer M, Oreb M, Boles E
Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS
Nat Commun 2018 Oct 19;9(1):4366
Hacker C, Cai X, Kegler C, Zhao L, Weickhmann AK, Wurm JP, Bode HB, Wöhnert J
Methionine-Containing Rhabdopeptide/Xenortide-like Peptides from Heterologous Expression of the Biosynthetic Gene Cluster kj12ABC in Escherichia coli
J Nat Prod 2018 Oct 26;81(10):2292-2295
Zhao L, Cai X, Kaiser M, Bode HB
Site-Specific Labelling of Multidomain Proteins by Amber Codon Suppression
Sci Rep 2018 Oct 5;8(1):14864
Heil CS, Rittner A, Goebel B, Beyer D, Grininger M
Dispersion Correction Alleviates Dye Stacking of Single-Stranded DNA and RNA in Simulations of Single-Molecule Fluorescence Experiments
J Phys Chem B 2018 Dec 13;122(49):11626-11639
Grotz KK, Nueesch MF, Holmstrom ED, Heinz M, Stelzl LS, Schuler B, Hummer G
Delocalized hole transport coupled to sub-ns tryptophanyl deprotonation promotes photoreduction of class II photolyases
Phys Chem Chem Phys 2018 Oct 10;20(39):25446-25457
Lacombat F, Espagne A, Dozova N, Plaza P, Ignatz E, Kiontke S, Essen LO
'Negative' and 'positive catalysis': complementary principles that shape the catalytic landscape of enzymes
Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs)
Chem Commun (Camb) 2018 Oct 11;54(82):11606-11609
Rossini E, Gajewski J, Klaus M, Hummer G, Grininger M
LILBID and nESI: Different Native Mass Spectrometry Techniques as Tools in Structural Biology
J Am Soc Mass Spectrom 2019 Jan;30(1):181-191
Peetz O, Hellwig N, Henrich E, Mezhyrova J, Dötsch V, Bernhard F, Morgner N
InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis
J Biol Chem 2018 Nov 2;293(44):17200-17207
Vögeli B, Rosenthal RG, Stoffel GMM, Wagner T, Kiefer P, Cortina NS, Shima S, Erb TJ
Precision DEER Distances from Spin-Label Ensemble Refinement
J Phys Chem Lett 2018 Oct 4;9(19):5748-5752
Reichel K, Stelzl LS, Köfinger J, Hummer G
A superfolder variant of pH-sensitive pHluorin for in vivo pH measurements in the endoplasmic reticulum
Sci Rep 2018 Aug 10;8(1):11985
Reifenrath M, Boles E
Rhabdopeptide/Xenortide-like Peptides from Xenorhabdus innexi with Terminal Amines Showing Potent Antiprotozoal Activity
Org Lett 2018 Sep 7;20(17):5116-5120
Zhao L, Kaiser M, Bode HB
NMR resonance assignments for the SAM/SAH-binding riboswitch RNA bound to S-adenosylhomocysteine
Biomol NMR Assign 2018 Oct;12(2):329-334
Weickhmann AK, Keller H, Duchardt-Ferner E, Strebitzer E, Juen MA, Kremser J, Wurm JP, Kreutz C, Wöhnert J
Bayesian inference of rotor ring stoichiometry from electron microscopy images of archaeal ATP synthase
Microscopy (Oxf) 2018 Oct 1;67(5):266-273
Cossio P, Allegretti M, Mayer F, Müller V, Vonck J, Hummer G
Structure of the bifunctional cryptochrome aCRY from Chlamydomonas reinhardtii
Nucleic Acids Res 2018 Sep 6;46(15):8010-8022
Franz S, Ignatz E, Wenzel S, Zielosko H, Putu EPGN, Maestre-Reyna M, Tsai MD, Yamamoto J, Mittag M, Essen LO
Adenine protonation enables cyclic-di-GMP binding to cyclic-GAMP sensing riboswitches
RNA 2018 Oct;24(10):1390-1402
Keller H, Weickhmann AK, Bock T, Wöhnert J
Hydrodynamics of Diffusion in Lipid Membrane Simulations
Phys Rev Lett 2018 Jun 29;120(26):268104
Vögele M, Köfinger J, Hummer G
Single-cell cloning enables the selection of more productive Drosophila melanogaster S2 cells for recombinant protein expression
Biotechnol Rep (Amst) 2018 Jul 3;19:e00272
Zitzmann J, Schreiber C, Eichmann J, Bilz RO, Salzig D, Weidner T, Czermak P
Molecular dynamics simulations of carbon nanotube porins in lipid bilayers
Faraday Discuss 2018 Sep 28;209(0):341-358
Vögele M, Köfinger J, Hummer G
Engineering strategies for rational polyketide synthase design
NMR resonance assignments for a ProQ homolog from Legionella pneumophila
Biomol NMR Assign 2018 Oct;12(2):319-322
Immer C, Hacker C, Wöhnert J
An engineered fatty acid synthase combined with a carboxylic acid reductase enables de novo production of 1-octanol in Saccharomyces cerevisiae
Biotechnol Biofuels 2018 Jun 1;11:150
Henritzi S, Fischer M, Grininger M, Oreb M, Boles E
Characterization of the small flavin-binding dodecin in the roseoflavin producer Streptomyces davawensis
Microbiology 2018 Jun;164(6):908-919
Ludwig P, Sévin DC, Busche T, Kalinowski J, Bourdeaux F, Grininger M, Mack M
Refining the Natural Product Repertoire in Entomopathogenic Bacteria
Trends Microbiol 2018 Oct;26(10):833-840
Tobias NJ, Shi YM, Bode HB
Rotational Diffusion Depends on Box Size in Molecular Dynamics Simulations
J Phys Chem Lett 2018 Jun 7;9(11):2874-2878
Linke M, Köfinger J, Hummer G
Structure, mechanism, and regulation of the chloroplast ATP synthase
Science 2018 May 11;360(6389)
Hahn A, Vonck J, Mills DJ, Meier T, Kühlbrandt W
Combining Promiscuous Acyl-CoA Oxidase and Enoyl-CoA Carboxylase/Reductases for Atypical Polyketide Extender Unit Biosynthesis
Cell Chem Biol 2018 Jul 19;25(7):833-839
Vögeli B, Geyer K, Gerlinger PD, Benkstein S, Cortina NS, Erb TJ
Sub-nanosecond tryptophan radical deprotonation mediated by a protein-bound water cluster in class II DNA photolyases
Chem Sci 2017 Dec 11;9(5):1200-1212
Müller P, Ignatz E, Kiontke S, Brettel K, Essen LO
Combined Approach of Backbone Amide Linking and On-Resin N-Methylation for the Synthesis of Bioactive and Metabolically Stable Peptides
J Med Chem 2018 May 10;61(9):3930-3938
Wesche F, Adihou H, Kaiser A, Wurglics M, Schubert-Zsilavecz M, Kaiser M, Bode HB
An engineered Calvin-Benson-Bassham cycle for carbon dioxide fixation in Methylobacterium extorquens AM1
Metab Eng 2018 May;47:423-433
Schada von Borzyskowski L, Carrillo M, Leupold S, Glatter T, Kiefer P, Weishaupt R, Heinemann M, Erb TJ
Flavin Storage and Sequestration by Mycobacterium tuberculosis Dodecin
ACS Infect Dis 2018 Jul 13;4(7):1082-1092
Bourdeaux F, Hammer CA, Vogt S, Schweighöfer F, Nöll G, Wachtveitl J, Grininger M
The benzodiazepine-like natural product tilivalline is produced by the entomopathogenic bacterium Xenorhabdus eapokensis
Likelihood-based structural analysis of electron microscopy images
Dielectric Spectroscopy and Optical Density Measurement for the Online Monitoring and Control of Recombinant Protein Production in Stably Transformed Drosophila melanogaster S2 Cells
Sensors (Basel) 2018 Mar 18;18(3)
Zitzmann J, Weidner T, Eichner G, Salzig D, Czermak P
Retinal isomerization and water-pore formation in channelrhodopsin-2
Structure of the catalytic F(1) head of the F(1)-F(o) ATP synthase from Trypanosoma brucei
Conserved in situ arrangement of complex I and III(2) in mitochondrial respiratory chain supercomplexes of mammals, yeast, and plants
Natural Product Diversification Mediated by Alternative Transcriptional Starting
Georatusin, a Specific Antiparasitic Polyketide-Peptide Hybrid from the Fungus Geomyces auratus
Org Lett 2018 Mar 16;20(6):1563-1567
Shi YM, Richter C, Challinor VL, Grün P, Girela Del Rio A, Kaiser M, Schüffler A, Piepenbring M, Schwalbe H, Bode HB
Cryo-electron tomography analyses of terminal organelle mutants suggest the motility mechanism of Mycoplasma genitalium
Mol Microbiol 2018 May;108(3):319-329
Seybert A, Gonzalez-Gonzalez L, Scheffer MP, Lluch-Senar M, Mariscal AM, Querol E, Matthaeus F, Piñol J, Frangakis AS
Mitochondrial Respiratory Chain Complexes
Subcell Biochem 2018;87:167-227
Sousa JS, D'Imprima E, Vonck J
De novo design and engineering of non-ribosomal peptide synthetases
Nat Chem 2018 Mar;10(3):275-281
Bozhüyük KAJ, Fleischhacker F, Linck A, Wesche F, Tietze A, Niesert CP, Bode HB
Metabolomics-based chemotaxonomy of root endophytic fungi for natural products discovery
Environ Microbiol 2018 Mar;20(3):1253-1270
Maciá-Vicente JG, Shi YN, Cheikh-Ali Z, Grün P, Glynou K, Kia SH, Piepenbring M, Bode HB
Fully Anisotropic Rotational Diffusion Tensor from Molecular Dynamics Simulations
J Phys Chem B 2018 May 31;122(21):5630-5639
Linke M, Köfinger J, Hummer G
Chemical language and warfare of bacterial natural products in bacteria-nematode-insect interactions
Engineering of hydroxymandelate synthases and the aromatic amino acid pathway enables de novo biosynthesis of mandelic and 4-hydroxymandelic acid with Saccharomyces cerevisiae
Metab Eng 2018 Jan;45:246-254
Reifenrath M, Boles E
Characterization of the Polyspecific Transferase of Murine Type I Fatty Acid Synthase (FAS) and Implications for Polyketide Synthase (PKS) Engineering
ACS Chem Biol 2018 Mar 16;13(3):723-732
Rittner A, Paithankar KS, Huu KV, Grininger M
High titer oncolytic measles virus production process by integration of dielectric spectroscopy as online monitoring system
Biotechnol Bioeng 2018 May;115(5):1186-1194
Grein TA, Loewe D, Dieken H, Salzig D, Weidner T, Czermak P
Molecular Basis for Converting (2S)-Methylsuccinyl-CoA Dehydrogenase into an Oxidase
Molecules 2017 Dec 28;23(1)
Burgener S, Schwander T, Romero E, Fraaije MW, Erb TJ
Structural basis for substrate specificity of methylsuccinyl-CoA dehydrogenase, an unusual member of the acyl-CoA dehydrogenase family
J Biol Chem 2018 Feb 2;293(5):1702-1712
Schwander T, McLean R, Zarzycki J, Erb TJ
Structural basis of proton translocation and force generation in mitochondrial ATP synthase
Elife 2017 Dec 6;6
Klusch N, Murphy BJ, Mills DJ, Yildiz Ö, Kühlbrandt W
Optimisation of trans-cinnamic acid and hydrocinnamyl alcohol production with recombinant Saccharomyces cerevisiae and identification of cinnamyl methyl ketone as a by-product
FEMS Yeast Res 2017 Dec 1;17(8)
Gottardi M, Grün P, Bode HB, Hoffmann T, Schwab W, Oreb M, Boles E
Reassessment of inclusion body-based production as a versatile opportunity for difficult-to-express recombinant proteins
Crit Rev Biotechnol 2018 Aug;38(5):729-744
Hoffmann D, Ebrahimi M, Gerlach D, Salzig D, Czermak P
Classical Molecular Dynamics with Mobile Protons
Scaffolding the cup-shaped double membrane in autophagy
PLoS Comput Biol 2017 Oct 24;13(10):e1005817
Bahrami AH, Lin MG, Ren X, Hurley JH, Hummer G
Dynamic Histogram Analysis To Determine Free Energies and Rates from Biased Simulations
J Chem Theory Comput 2017 Dec 12;13(12):6328-6342
Stelzl LS, Kells A, Rosta E, Hummer G
Transition path sampling of rare events by shooting from the top
J Chem Phys 2017 Oct 21;147(15):152716
Jung H, Okazaki KI, Hummer G
Insights into Cotranslational Membrane Protein Insertion by Combined LILBID-Mass Spectrometry and NMR Spectroscopy
Anal Chem 2017 Nov 21;89(22):12314-12318
Peetz O, Henrich E, Laguerre A, Löhr F, Hein C, Dötsch V, Bernhard F, Morgner N
NMR experiments for the rapid identification of P=O···H-X type hydrogen bonds in nucleic acids
J Biomol NMR 2017 Oct;69(2):101-110
Duchardt-Ferner E, Wöhnert J
Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus
Nat Microbiol 2017 Dec;2(12):1676-1685
Tobias NJ, Wolff H, Djahanschiri B, Grundmann F, Kronenwerth M, Shi YM, Simonyi S, Grün P, Shapiro-Ilan D, Pidot SJ, Stinear TP, Ebersberger I, Bode HB
Biosynthesis and function of simple amides in Xenorhabdus doucetiae
Environ Microbiol 2017 Nov;19(11):4564-4575
Bode E, He Y, Vo TD, Schultz R, Kaiser M, Bode HB
Formation and Stability of Lipid Membrane Nanotubes
Non-invasive Raman Spectroscopy and Quantitative Real-Time PCR Distinguish Among Undifferentiated Human Mesenchymal Stem Cells and Redifferentiated Nucleus Pulposus Cells and Chondrocytes In Vitro
Open Biomed Eng J 2017 Jul 31;11:72-84
Ehlicke F, Köster N, Salzig D, Czermak P
Nicotinamide Adenine Dinucleotides Arrest Photoreduction of Class II DNA Photolyases in FADH(˙) State
Photochem Photobiol 2018 Jan;94(1):81-87
Ignatz E, Geisselbrecht Y, Kiontke S, Essen LO
Baculovirus-induced recombinant protein expression in human mesenchymal stromal stem cells: A promoter study
N Biotechnol 2017 Oct 25;39(Pt B):161-166
Sprick G, Weidner T, Salzig D, Czermak P
The components of shear stress affecting insect cells used with the baculovirus expression vector system
Z Naturforsch C J Biosci 2017 Sep 26;72(9-10):429-439
Weidner T, Druzinec D, Mühlmann M, Buchholz R, Czermak P
Cryo-EM Structure of the TOM Core Complex from Neurospora crassa
Cell 2017 Aug 10;170(4):693-700
Bausewein T, Mills DJ, Langer JD, Nitschke B, Nussberger S, Kühlbrandt W
Resolving the Conformational Dynamics of DNA with Ångstrom Resolution by Pulsed Electron-Electron Double Resonance and Molecular Dynamics
J Am Chem Soc 2017 Aug 30;139(34):11674-11677
Stelzl LS, Erlenbach N, Heinz M, Prisner TF, Hummer G
Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila
Elife 2017 Jul 12;6
Brandt T, Mourier A, Tain LS, Partridge L, Larsson NG, Kühlbrandt W
Strategies in megasynthase engineering - fatty acid synthases (FAS) as model proteins
Structural characterization of the NAP; the major adhesion complex of the human pathogen Mycoplasma genitalium
Mol Microbiol 2017 Sep;105(6):869-879
Scheffer MP, Gonzalez-Gonzalez L, Seybert A, Ratera M, Kunz M, Valpuesta JM, Fita I, Querol E, Piñol J, Martín-Benito J, Frangakis AS
LuxS-dependent AI-2 production is not involved in global regulation of natural product biosynthesis in Photorhabdus and Xenorhabdus
PeerJ 2017 Jun 26;5:e3471
Heinrich AK, Hirschmann M, Neubacher N, Bode HB
Kinetics from Replica Exchange Molecular Dynamics Simulations
Identification and occurrence of the hydroxamate siderophores aerobactin, putrebactin, avaroferrin and ochrobactin C as virulence factors from entomopathogenic bacteria
Environ Microbiol 2017 Oct;19(10):4080-4090
Hirschmann M, Grundmann F, Bode HB
Structure and in situ organisation of the Pyrococcus furiosus archaellum machinery
Elife 2017 Jun 27;6
Daum B, Vonck J, Bellack A, Chaudhury P, Reichelt R, Albers SV, Rachel R, Kühlbrandt W
Secretion of 2,3-dihydroxyisovalerate as a limiting factor for isobutanol production in Saccharomyces cerevisiae
FEMS Yeast Res 2017 May 1;17(3)
Generoso WC, Brinek M, Dietz H, Oreb M, Boles E
A conserved threonine prevents self-intoxication of enoyl-thioester reductases
Nat Chem Biol 2017 Jul;13(7):745-749
Rosenthal RG, Vögeli B, Wagner T, Shima S, Erb TJ
Position-Dependent Diffusion Tensors in Anisotropic Media from Simulation: Oxygen Transport in and through Membranes
J Chem Theory Comput 2017 Jun 13;13(6):2962-2976
Ghysels A, Venable RM, Pastor RW, Hummer G
Anaerobic Membrane Bioreactor for Continuous Lactic Acid Fermentation
Membranes (Basel) 2017 May 3;7(2)
Fan R, Ebrahimi M, Czermak P
Microbiology: A new language for small talk
Solid-phase enrichment and analysis of electrophilic natural products
Structure and Biosynthesis of Isatropolones, Bioactive Amine-Scavenging Fluorescent Natural Products from Streptomyces Gö66
Angew Chem Int Ed Engl 2017 Apr 24;56(18):4945-4949
Cai X, Shi YM, Pöhlmann N, Revermann O, Bahner I, Pidot SJ, Wesche F, Lackner H, Büchel C, Kaiser M, Richter C, Schwalbe H, Stinear TP, Zeeck A, Bode HB
De novo biosynthesis of trans-cinnamic acid derivatives in Saccharomyces cerevisiae
Appl Microbiol Biotechnol 2017 Jun;101(12):4883-4893
Gottardi M, Knudsen JD, Prado L, Oreb M, Branduardi P, Boles E
Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design
Nat Chem 2017 Apr;9(4):379-386
Cai X, Nowak S, Wesche F, Bischoff I, Kaiser M, Fürst R, Bode HB
Engineering fungal de novo fatty acid synthesis for short chain fatty acid production
Nat Commun 2017 Mar 10;8:14650
Gajewski J, Pavlovic R, Fischer M, Boles E, Grininger M
The Global Regulators Lrp, LeuO, and HexA Control Secondary Metabolism in Entomopathogenic Bacteria
Front Microbiol 2017 Feb 17;8:209
Engel Y, Windhorst C, Lu X, Goodrich-Blair H, Bode HB
Engineering fatty acid synthases for directed polyketide production
Nat Chem Biol 2017 Apr;13(4):363-365
Gajewski J, Buelens F, Serdjukow S, Janßen M, Cortina N, Grubmüller H, Grininger M
Expanding the product portfolio of fungal type I fatty acid synthases
Nat Chem Biol 2017 Apr;13(4):360-362
Zhu Z, Zhou YJ, Krivoruchko A, Grininger M, Zhao ZK, Nielsen J
A high-throughput expression screening platform to optimize the production of antimicrobial peptides
Microb Cell Fact 2017 Feb 13;16(1):29
Schreiber C, Müller H, Birrenbach O, Klein M, Heerd D, Weidner T, Salzig D, Czermak P
Biosynthesis of the Antibiotic Nematophin and Its Elongated Derivatives in Entomopathogenic Bacteria
Org Lett 2017 Feb 17;19(4):806-809
Cai X, Challinor VL, Zhao L, Reimer D, Adihou H, Grün P, Kaiser M, Bode HB
Optimized expression of the antimicrobial protein Gloverin from Galleria mellonella using stably transformed Drosophila melanogaster S2 cells
Cytotechnology 2017 Apr;69(2):371-389
Zitzmann J, Weidner T, Czermak P
Carbon Nanotubes Mediate Fusion of Lipid Vesicles
ACS Nano 2017 Feb 28;11(2):1273-1280
Bhaskara RM, Linker SM, Vögele M, Köfinger J, Hummer G
Natural Products from Photorhabdus and Other Entomopathogenic Bacteria
Curr Top Microbiol Immunol 2017;402:55-79
Bozhüyük KAJ, Zhou Q, Engel Y, Heinrich A, Pérez A, Bode HB
Analyzing native membrane protein assembly in nanodiscs by combined non-covalent mass spectrometry and synthetic biology
Elife 2017 Jan 9;6
Henrich E, Peetz O, Hein C, Laguerre A, Hoffmann B, Hoffmann J, Dötsch V, Bernhard F, Morgner N
Screening different host cell lines for the dynamic production of measles virus
Biotechnol Prog 2017 Jul;33(4):989-997
Grein TA, Schwebel F, Kress M, Loewe D, Dieken H, Salzig D, Weidner T, Czermak P
A Stably Protonated Adenine Nucleotide with a Highly Shifted pK(a) Value Stabilizes the Tertiary Structure of a GTP-Binding RNA Aptamer
Angew Chem Int Ed Engl 2017 Jan 2;56(1):401-404
Wolter AC, Weickhmann AK, Nasiri AH, Hantke K, Ohlenschläger O, Wunderlich CH, Kreutz C, Duchardt-Ferner E, Wöhnert J
NMR resonance assignments for the tetramethylrhodamine binding RNA aptamer 3 in complex with the ligand 5-carboxy-tetramethylrhodamine
Biomol NMR Assign 2017 Apr;11(1):29-34
Duchardt-Ferner E, Juen M, Kreutz C, Wöhnert J
Photorhabdus-nematode symbiosis is dependent on hfq-mediated regulation of secondary metabolites
Environ Microbiol 2017 Jan;19(1):119-129
Tobias NJ, Heinrich AK, Eresmann H, Wright PR, Neubacher N, Backofen R, Bode HB
Three-dimensional CTF correction improves the resolution of electron tomograms



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