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This page was auto-generated from NCBI/Pubmed on Mi 20 Nov 2024 23:20:35 CET
Layered entrenchment maintains essentiality in the evolution of Form I Rubisco complexes
EMBO J 2024 Nov 18.
Schulz L;Zarzycki J;Steinchen W;Hochberg GKA;Erb TJ;
The Kinetics of Carbon-Carbon-Bond Formation in Metazoan Fatty Acid Synthase and its Impact on Product Fidelity
Angew Chem Int Ed Engl 2024 Nov 11:e202412195.
Gusenda C;Grininger M;Fernandes PA;Calixto AR;da Silva JMR;
Refined Protein-Sugar Interactions in the Martini Force Field
J Chem Theory Comput 2024 Nov 8.
Heidari M;Sikora M;Hummer G;
Pyrrolizwilline, a Unique Bacterial Alkaloid Assembled by a Nonribosomal Peptide Synthetase and non-Enzymatic Dimerization
Angew Chem Int Ed Engl 2024 Oct 20:e202411258.
Effert J;Westphalen M;Calderari A;Shi YM;Elamri I;Najah S;Grün P;Li Y;Gruez A;Weissman KJ;Bode HB;
Adaptive laboratory evolution recruits the promiscuity of succinate semialdehyde dehydrogenase to repair different metabolic deficiencies
Nat Commun 2024 Oct 15;15(1):8898.
He H;Gómez-Coronado PA;Zarzycki J;Barthel S;Kahnt J;Claus P;Klein M;Klose M;de Crécy-Lagard V;Schindler D;Paczia N;Glatter T;Erb TJ;
In vitro transcription-based biosensing of glycolate for prototyping of a complex enzyme cascade
Synth Biol (Oxf) 2024 Sep 20;9(1):ysae013.
Barthel S;Brenker L;Diehl C;Bohra N;Giaveri S;Paczia N;Erb TJ;
In situ structure and rotary states of mitochondrial ATP synthase in whole Polytomella cells
Science 2024 Sep 6;385(6713):1086-1090.
Dietrich L;Agip AA;Kunz C;Schwarz A;Kühlbrandt W;
Isofunctional but Structurally Different Methyltransferases for Dithiolopyrrolone Diversification
Angew Chem Int Ed Engl 2024 Aug 26:e202410799.
Su L;Huber EM;Westphalen M;Gellner J;Bode E;Köbel T;Grün P;Alanjary MM;Glatter T;Cirnski K;Müller R;Schindler D;Groll M;Bode HB;
The malonyl/acetyl-transferase from murine fatty acid synthase is a promiscuous engineering tool for editing polyketide scaffolds
Commun Chem 2024 Aug 24;7(1):187.
Buyachuihan L;Reiners S;Zhao Y;Grininger M;
Integrated translation and metabolism in a partially self-synthesizing biochemical network
Science 2024 Jul 12;385(6705):174-178.
Giaveri S;Bohra N;Diehl C;Yang HY;Ballinger M;Paczia N;Glatter T;Erb TJ;
Multiple levels of transcriptional regulation control glycolate metabolism in Paracoccus denitrificans
mBio 2024 Aug 14;15(8):e0152424.
Schada von Borzyskowski L;Hermann L;Kremer K;Barthel S;Pommerenke B;Glatter T;Paczia N;Bremer E;Erb TJ;
Enhanced production of trans-cinnamic acid in Photorhabdus luminescens with homolog expression and deletion strategies
J Appl Microbiol 2024 Jul 2;135(7):lxae149.
Ulgen Gokduman F;Yılmaz S;Bode HB;
Investigation of the Odilorhabdin Biosynthetic Gene Cluster Using NRPS Engineering
Angew Chem Int Ed Engl 2024 Aug 12;63(33):e202406389.
Präve L;Seyfert CE;Bozhüyük KAJ;Racine E;Müller R;Bode HB;
Structure of an internal loop motif with three consecutive U•U mismatches from stem-loop 1 in the 3'-UTR of the SARS-CoV-2 genomic RNA
Nucleic Acids Res 2024 Jun 24;52(11):6687-6706.
Vögele J;Duchardt-Ferner E;Bains JK;Knezic B;Wacker A;Sich C;Weigand JE;Šponer J;Schwalbe H;Krepl M;Wöhnert J;
Time-Resolved Ion Mobility Mass Spectrometry to Solve Conformational Changes in a Cryptochrome
J Am Chem Soc 2024 May 29;146(21):14468-14478.
Zangl R;Soravia S;Saft M;Löffler JG;Schulte J;Rosner CJ;Bredenbeck J;Essen LO;Morgner N;
High-confidence 3D template matching for cryo-electron tomography
Nat Commun 2024 May 11;15(1):3992.
Cruz-León S;Majtner T;Hoffmann PC;Kreysing JP;Kehl S;Tuijtel MW;Schaefer SL;Geißler K;Beck M;Turoňová B;Hummer G;
Genetic toolbox for Photorhabdus and Xenorhabdus: pSEVA based heterologous expression systems and CRISPR/Cpf1 based genome editing for rapid natural product profiling
Evolution-inspired engineering of nonribosomal peptide synthetases
Science 2024 Mar 22;383(6689):eadg4320.
Bozhüyük KAJ;Präve L;Kegler C;Schenk L;Kaiser S;Schelhas C;Shi YN;Kuttenlochner W;Schreiber M;Kandler J;Alanjary M;Mohiuddin TM;Groll M;Hochberg GKA;Bode HB;
Encoding prior knowledge in ensemble refinement
VitroJet: new features and case studies
Acta Crystallogr D Struct Biol 2024 Apr 1;80(Pt 4):232-246.
Henderikx RJM;Mann D;Domanska A;Dong J;Shahzad S;Lak B;Filopoulou A;Ludig D;Grininger M;Momoh J;Laanto E;Oksanen HM;Bisikalo K;Williams PA;Butcher SJ;Peters PJ;Beulen BWAMM;
Mechanism of proton-powered c-ring rotation in a mitochondrial ATP synthase
Using cryo-EM to understand the assembly pathway of respiratory complex I
Acta Crystallogr D Struct Biol 2024 Mar 1;80(Pt 3):159-173.
Laube E;Schiller J;Zickermann V;Vonck J;
Hierarchical Assembly of Single-Stranded RNA
Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore
Sci Adv 2024 Feb 9;10(6):eadj8027.
Rao S;Skulsuppaisarn M;Strong LM;Ren X;Lazarou M;Hurley JH;Hummer G;
Direct structural analysis of a single acyl carrier protein domain in fatty acid synthase from the fungus Saccharomyces cerevisiae
Commun Biol 2024 Jan 12;7(1):92.
Samani EK;Chen AC;Lou JW;Dai DL;Keszei AFA;Tan G;Boone C;Grininger M;Mazhab-Jafari MT;
Machine-guided path sampling to discover mechanisms of molecular self-organization
Nat Comput Sci 2023 Apr;3(4):334-345.
Jung H;Covino R;Arjun A;Leitold C;Dellago C;Bolhuis PG;Hummer G;
Creating new-to-nature carbon fixation: A guide
Metab Eng 2024 Mar:82:12-28.
Schulz-Mirbach H;Dronsella B;He H;Erb TJ;
One More for Light-triggered Conformational Changes in Cryptochromes: CryP from Phaeodactylum tricornutum
J Mol Biol 2024 Mar 1;436(5):168408.
Saft M;Schneider L;Ho CC;Maiterth E;Menke J;Sendker F;Steinchen W;Essen LO;
Neighbor List Artifacts in Molecular Dynamics Simulations
Machine Learning-Supported Enzyme Engineering toward Improved CO2-Fixation of Glycolyl-CoA Carboxylase
ACS Synth Biol 2023 Dec 15;12(12):3521-3530.
Marchal DG;Schulz L;Schuster I;Ivanovska J;Paczia N;Prinz S;Zarzycki J;Erb TJ;
Archaeal GPN-loop GTPases involve a lock-switch-rock mechanism for GTP hydrolysis
mBio 2023 Dec 19;14(6):e0085923.
Korf L;Ye X;Vogt MS;Steinchen W;Watad M;van der Does C;Tourte M;Sivabalasarma S;Albers S-V;Essen L-O;
Epitope characterization of proteins and aptamers with mass spectrometry
Cryo-electron tomography reveals the binding and release states of the major adhesion complex from Mycoplasma genitalium
PLoS Pathog 2023 Nov 8;19(11):e1011761.
Sprankel L;Scheffer MP;Manger S;Ermel UH;Frangakis AS;
Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides
Nat Commun 2023 Nov 8;14(1):7197.
Pandi A;Adam D;Zare A;Trinh VT;Schaefer SL;Burt M;Klabunde B;Bobkova E;Kushwaha M;Foroughijabbari Y;Braun P;Spahn C;Preußer C;Pogge von Strandmann E;Bode HB;von Buttlar H;Bertrams W;Jung AL;Abendroth F;Schmeck B;Hummer G;Vázquez O;Erb TJ;
How Acyl Carrier Proteins (ACPs) Direct Fatty Acid and Polyketide Biosynthesis
Angew Chem Int Ed Engl 2024 Jan 22;63(4):e202312476.
Buyachuihan L;Stegemann F;Grininger M;
Efficient generation of random rotation matrices in four dimensions
Phys Rev E 2023 Sep;108(3-2):035307.
Bullerjahn JT;Fábián B;Hummer G;
Photosynthesis 2.0: Realizing New-to-Nature CO2-Fixation to Overcome the Limits of Natural Metabolism
Two conformations of the Tom20 preprotein receptor in the TOM holo complex
Proc Natl Acad Sci U S A 2023 Aug 22;120(34):e2301447120.
Ornelas P;Bausewein T;Martin J;Morgner N;Nussberger S;Kühlbrandt W;
Guidelines for Optimizing Type S Nonribosomal Peptide Synthetases
ACS Synth Biol 2023 Aug 18;12(8):2432-2443.
Abbood N;Effert J;Bozhueyuek KAJ;Bode HB;
easyPACId, a Simple Method for Induced Production, Isolation, Identification, and Testing of Natural Products from Proteobacteria
Bio Protoc 2023 Jul 5;13(13):e4709.
Bode E;Assmann D;Happel P;Meyer E;Münch K;Rössel N;Bode HB;
CryoEM analysis of the essential native UDP-glucose pyrophosphorylase from Aspergillus nidulans reveals key conformations for activity regulation and function
mBio 2023 Aug 31;14(4):e0041423.
Han X;D'Angelo C;Otamendi A;Cifuente JO;de Astigarraga E;Ochoa-Lizarralde B;Grininger M;Routier FH;Guerin ME;Fuehring J;Etxebeste O;Connell SR;
Docking Domain Engineering in a Modular Polyketide Synthase and Its Impact on Structure and Function
ACS Chem Biol 2023 Jul 21;18(7):1500-1509.
Buyachuihan L;Zhao Y;Schelhas C;Grininger M;
Draft genomes, phylogenomic reconstruction and comparative genome analysis of three Xenorhabdus strains isolated from soil-dwelling nematodes in Kenya
Access Microbiol 2023 May 22;5(5):acmi000531.v4.
Awori RM;Waturu CN;Pidot SJ;Amugune NO;Bode HB;
Functional Degeneracy in Paracoccus denitrificans Pd1222 Is Coordinated via RamB, Which Links Expression of the Glyoxylate Cycle to Activity of the Ethylmalonyl-CoA Pathway
Appl Environ Microbiol 2023 Jul 26;89(7):e0023823.
Kremer K;Meier D;Theis L;Miller S;Rost-Nasshan A;Naing YT;Zarzycki J;Paczia N;Serrania J;Blumenkamp P;Goesmann A;Becker A;Thanbichler M;Hochberg GKA;Carter MS;Erb TJ;
Exploring alternative pathways for the in vitro establishment of the HOPAC cycle for synthetic CO2 fixation
Sci Adv 2023 Jun 16;9(24):eadh4299.
McLean R;Schwander T;Diehl C;Cortina NS;Paczia N;Zarzycki J;Erb TJ;
Unwrapping NPT Simulations to Calculate Diffusion Coefficients
J Chem Theory Comput 2023 Jun 13;19(11):3406-3417.
Bullerjahn JT;von Bülow S;Heidari M;Hénin J;Hummer G;
Enhancing the Substrate Specificity of Clostridium Succinyl-CoA Reductase for Synthetic Biology and Biocatalysis
Biochemistry 2023 Jun 6;62(11):1786-1793.
Pfister P;Diehl C;Hammarlund E;Carrillo M;Erb TJ;
A Practical Guideline to Engineering Nonribosomal Peptide Synthetases
Methods Mol Biol 2023:2670:219-234.
Abbood N;Präve L;Bozhueyuek KAJ;Bode HB;
Engineering a new-to-nature cascade for phosphate-dependent formate to formaldehyde conversion in vitro and in vivo
Nat Commun 2023 May 9;14(1):2682.
Nattermann M;Wenk S;Pfister P;He H;Lee SH;Szymanski W;Guntermann N;Zhu F;Nickel L;Wallner C;Zarzycki J;Paczia N;Gaißert N;Franciò G;Leitner W;Gonzalez R;Erb TJ;
An optimized reverse β-oxidation pathway to produce selected medium-chain fatty acids in Saccharomyces cerevisiae
Biotechnol Biofuels Bioprod 2023 Apr 26;16(1):71.
Garces Daza F;Haitz F;Born A;Boles E;
Development of vitamin B12 dependency in Saccharomyces cerevisiae
Enzymology of assembly line synthesis by modular polyketide synthases
Peroxisomal metabolic coupling improves fatty alcohol production from sole methanol in yeast
Structural and dynamic effects of pseudouridine modifications on noncanonical interactions in RNA
RNA 2023 Jun;29(6):790-807.
Vögele J;Duchardt-Ferner E;Kruse H;Zhang Z;Sponer J;Krepl M;Wöhnert J;
Optimal Bond Constraint Topology for Molecular Dynamics Simulations of Cholesterol
Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas
Nat Struct Mol Biol 2023 Mar;30(3):321-329.
Sprankel L;Vizarraga D;Martín J;Manger S;Meier-Credo J;Marcos M;Julve J;Rotllan N;Scheffer MP;Escolà-Gil JC;Langer JD;Piñol J;Fita I;Frangakis AS;
Implementation of the β-hydroxyaspartate cycle increases growth performance of Pseudomonas putida on the PET monomer ethylene glycol
Metab Eng 2023 Mar:76:97-109.
Schada von Borzyskowski L;Schulz-Mirbach H;Troncoso Castellanos M;Severi F;Gómez-Coronado PA;Paczia N;Glatter T;Bar-Even A;Lindner SN;Erb TJ;
Antibody accessibility determines location of spike surface mutations in SARS-CoV-2 variants
PLoS Comput Biol 2023 Jan 24;19(1):e1010822.
von Bülow S;Sikora M;Blanc FEC;Covino R;Hummer G;
Structural and Functional Analysis of a Prokaryotic (6-4) Photolyase from the Aquatic Pathogen Vibrio Cholerae†
Photochem Photobiol 2023 Sep-Oct;99(5):1248-1257.
Emmerich HJ;Schneider L;Essen LO;
Analysis of the conformational heterogeneity of the Rieske iron-sulfur protein in complex III2 by cryo-EM
IUCrJ 2023 Jan 1;10(Pt 1):27-37.
Wieferig JP;Kühlbrandt W;
Engineering of Specific Single-Module Nonribosomal Peptide Synthetases of the RXP Type for the Production of Defined Peptides
Structural Basis for a Cork-Up Mechanism of the Intra-Molecular Mesaconyl-CoA Transferase
Biochemistry 2023 Jan 3;62(1):75-84.
Pfister P;Zarzycki J;Erb TJ;
Synthetic anaplerotic modules for the direct synthesis of complex molecules from CO2
Nat Chem Biol 2023 Feb;19(2):168-175.
Diehl C;Gerlinger PD;Paczia N;Erb TJ;
Structural ensembles of disordered proteins from hierarchical chain growth and simulation
Curr Opin Struct Biol 2023 Feb:78:102501.
Pietrek LM;Stelzl LS;Hummer G;
Complexes++: Efficient and versatile coarse-grained simulations of protein complexes and their dense solutions
J Chem Phys 2022 Nov 28;157(20):204802.
Linke M;Quoika PK;Bramas B;Köfinger J;Hummer G;
Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum
Sci Adv 2022 Nov 25;8(47):eadc9952.
Laube E;Meier-Credo J;Langer JD;Kühlbrandt W;
Multiple Functions of the Type II Thioesterase Associated with the Phoslactomycin Polyketide Synthase
Biochemistry 2022 Dec 6;61(23):2662-2671.
Geyer K;Hartmann S;Singh RR;Erb TJ;
Sublytic gasdermin-D pores captured in atomistic molecular simulations
Elife 2022 Nov 14:11:e81432.
Schaefer SL;Hummer G;
TriMem: A parallelized hybrid Monte Carlo software for efficient simulations of lipid membranes
J Chem Phys 2022 Nov 7;157(17):174801.
Siggel M;Kehl S;Reuter K;Köfinger J;Hummer G;
Concluding remarks: Challenges and future developments in biological electron cryo-microscopy
ArtiaX: An electron tomography toolbox for the interactive handling of sub-tomograms in UCSF ChimeraX
Protein Sci 2022 Dec;31(12):e4472.
Ermel UH;Arghittu SM;Frangakis AS;
Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate-Containing Natural Products in Diverse Bacteria
Angew Chem Int Ed Engl 2022 Dec 19;61(51):e202206106.
Shi YM;Crames JJ;Czech L;Bozhüyük KAJ;Shi YN;Hirschmann M;Lamberth S;Claus P;Paczia N;Rückert C;Kalinowski J;Bange G;Bode HB;
Nanoporous Membranes of Densely Packed Carbon Nanotubes Formed by Lipid-Mediated Self-Assembly
ACS Appl Bio Mater 2024 Feb 19;7(2):528-534.
Vögele M;Köfinger J;Hummer G;
A New Control Strategy for High-Pressure Homogenization to Improve the Safety of Injectable Lipid Emulsions
Pharmaceutics 2022 Jul 31;14(8):1603.
Grumbach C;Krüger V;Czermak P;
Chemoenzymatic synthesis of fluorinated polyketides
Nat Chem 2022 Sep;14(9):1000-1006.
Rittner A;Joppe M;Schmidt JJ;Mayer LM;Reiners S;Heid E;Herzberg D;Sherman DH;Grininger M;
Small ionic radii limit time step in Martini 3 molecular dynamics simulations
J Chem Phys 2022 Jul 21;157(3):034101.
Fábián B;Thallmair S;Hummer G;
Cleavage Off-Loading and Post-assembly-Line Conversions Yield Products with Unusual Termini during Biosynthesis
ACS Chem Biol 2022 Aug 19;17(8):2221-2228.
Shi YM;Hirschmann M;Shi YN;Bode HB;
Pathway and protein engineering for biosynthesis
A versatile active learning workflow for optimization of genetic and metabolic networks
Nat Commun 2022 Jul 5;13(1):3876.
Pandi A;Diehl C;Yazdizadeh Kharrazi A;Scholz SA;Bobkova E;Faure L;Nattermann M;Adam D;Chapin N;Foroughijabbari Y;Moritz C;Paczia N;Cortina NS;Faulon JL;Erb TJ;
LILBID-MS: using lasers to shed light on biomolecular architectures
Structural insights into the mechanism of archaellar rotational switching
Nat Commun 2022 May 23;13(1):2857.
Altegoer F;Quax TEF;Weiland P;Nußbaum P;Giammarinaro PI;Patro M;Li Z;Oesterhelt D;Grininger M;Albers SV;Bange G;
Hot-Water Hemicellulose Extraction from Fruit Processing Residues
ACS Omega 2022 Apr 12;7(16):13436-13447.
Wolf M;Berger F;Hanstein S;Weidenkaff A;Endreß HU;Oestreich AM;Ebrahimi M;Czermak P;
Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria
Nat Chem 2022 Jun;14(6):701-712.
Shi YM;Hirschmann M;Shi YN;Ahmed S;Abebew D;Tobias NJ;Grün P;Crames JJ;Pöschel L;Kuttenlochner W;Richter C;Herrmann J;Müller R;Thanwisai A;Pidot SJ;Stinear TP;Groll M;Kim Y;Bode HB;
Screening for Biofilm-Stimulating Factors in the Freshwater Planctomycete Planctopirus limnophila to Improve Sessile Growth in a Chemically Defined Medium
Global Structure of the Intrinsically Disordered Protein Tau Emerges from Its Local Structure
JACS Au 2022 Mar 1;2(3):673-686.
Stelzl LS;Pietrek LM;Holla A;Oroz J;Sikora M;Köfinger J;Schuler B;Zweckstetter M;Hummer G;
Forty years in cryoEM of membrane proteins
Bacterial F-type ATP synthases follow a well-choreographed assembly pathway
Nat Commun 2022 Mar 8;13(1):1218.
Vu Huu K;Zangl R;Hoffmann J;Just A;Morgner N;
A Combined Ultrafiltration/Diafiltration Process for the Purification of Oncolytic Measles Virus
Membranes (Basel) 2022 Jan 18;12(2):105.
Loewe D;Dieken H;Grein TA;Salzig D;Czermak P;
1H, 13C and 15N chemical shift assignment of the stem-loops 5b + c from the 5'-UTR of SARS-CoV-2
Biomol NMR Assign 2022 Apr;16(1):17-25.
Mertinkus KR;Grün JT;Altincekic N;Bains JK;Ceylan B;Ferner JP;Frydman L;Fürtig B;Hengesbach M;Hohmann KF;Hymon D;Kim J;Knezic B;Novakovic M;Oxenfarth A;Peter SA;Qureshi NS;Richter C;Scherf T;Schlundt A;Schnieders R;Schwalbe H;Stirnal E;Sudakov A;Vögele J;Wacker A;Weigand JE;Wirmer-Bartoschek J;Martin MAW;Wöhnert J;
Type S Non-Ribosomal Peptide Synthetases for the Rapid Generation of Tailormade Peptide Libraries
Chemistry 2022 May 6;28(26):e202103963.
Abbood N;Duy Vo T;Watzel J;Bozhueyuek KAJ;Bode HB;
Mean curvature motion facilitates the segmentation and surface visualization of electron tomograms
Process intensification for the continuous production of an antimicrobial peptide in stably-transformed Sf-9 insect cells
Sci Rep 2022 Jan 20;12(1):1086.
Käßer L;Rotter M;Coletta L;Salzig D;Czermak P;
Uncovering Nematicidal Natural Products from Xenorhabdus Bacteria
J Agric Food Chem 2022 Jan 19;70(2):498-506.
Abebew D;Sayedain FS;Bode E;Bode HB;
Solution Structure and Conformational Flexibility of a Polyketide Synthase Module
JACS Au 2021 Oct 18;1(12):2162-2171.
Klaus M;Rossini E;Linden A;Paithankar KS;Zeug M;Ignatova Z;Urlaub H;Khosla C;Köfinger J;Hummer G;Grininger M;
A novel class of Candida glabrata cell wall proteins with β-helix fold mediates adhesion in clinical isolates
PLoS Pathog 2021 Dec 28;17(12):e1009980.
Reithofer V;Fernández-Pereira J;Alvarado M;de Groot P;Essen LO;
Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle
Sci Adv 2021 Dec 24;7(52):eabk2392.
Ellinghaus TL;Marcellino T;Srinivasan V;Lill R;Kühlbrandt W;
It's noisy out there! A review of denoising techniques in cryo-electron tomography
Conformational Change of Tetratricopeptide Repeats Region Triggers Activation of Phytochrome-Associated Protein Phosphatase 5
In situ purification and enrichment of fructo-oligosaccharides by fermentative treatment with Bacillus coagulans and selective catalysis using immobilized fructosyltransferase
Bioresour Technol 2021 Dec:342:125969.
Fan R;Dresler J;Tissen D;Wen L;Czermak P;
Engineering a Highly Efficient Carboligase for Synthetic One-Carbon Metabolism
ACS Catal 2021 May 7;11(9):5396-5404.
Nattermann M;Burgener S;Pfister P;Chou A;Schulz L;Lee SH;Paczia N;Zarzycki J;Gonzalez R;Erb TJ;
Light-powered CO(2) fixation in a chloroplast mimic with natural and synthetic parts
Science 2020 May 8;368(6491):649-654
Miller TE, Beneyton T, Schwander T, Diehl C, Girault M, McLean R, Chotel T, Claus P, Cortina NS, Baret JC, Erb TJ
Non-ribosomal peptides produced by minimal and engineered synthetases with terminal reductase domains
Chembiochem 2020 May 7
Tietze A, Shi YN, Kronenwerth M, Bode HB
Artificial Splitting of a Non-Ribosomal Peptide Synthetase by Inserting Natural Docking Domains
The role of the iterative modules in polyketide synthase evolution
Understanding Substrate Selectivity of Phoslactomycin Polyketide Synthase by Using Reconstituted in Vitro Systems
Chembiochem 2020 Mar 30
Geyer K, Sundaram S, Sušnik P, Koert U, Erb TJ
A New Docking Domain Type in the Peptide-Antimicrobial-Xenorhabdus Peptide Producing Nonribosomal Peptide Synthetase from Xenorhabdus bovienii
ACS Chem Biol 2020 Apr 17;15(4):982-989
Watzel J, Hacker C, Duchardt-Ferner E, Bode HB, Wöhnert J
The resolution revolution in cryoEM requires high-quality sample preparation: a rapid pipeline to a high-resolution map of yeast fatty acid synthase
IUCrJ 2020 Jan 25;7(Pt 2):220-227
Joppe M, D'Imprima E, Salustros N, Paithankar KS, Vonck J, Grininger M, Kühlbrandt W
Reply to Desikan et al
: Micelle formation among various mechanisms of toxin pore formation Proc Natl Acad Sci U S A
Vögele M, Bhaskara RM, Mulvihill E, van Pee K, Yildiz Ö, Kühlbrandt W, Müller DJ, Hummer G
Innovative Optical-Sensing Technology for the Online Fouling Characterization of Silicon Carbide Membranes during the Treatment of Oily Water
Sensors (Basel) 2020 Feb 20;20(4)
Ebrahimi M, Schmidt AA, Kaplan C, Schmitz O, Czermak P
Analysis of the co-translational assembly of the fungal fatty acid synthase (FAS)
Sci Rep 2020 Jan 21;10(1):895
Fischer M, Joppe M, Mulinacci B, Vollrath R, Konstantinidis K, Kötter P, Ciccarelli L, Vonck J, Oesterhelt D, Grininger M
Opportunities to debottleneck the downstream processing of the oncolytic measles virus
Crit Rev Biotechnol 2020 Mar;40(2):247-264
Loewe D, Dieken H, Grein TA, Weidner T, Salzig D, Czermak P
Oxalyl-CoA Decarboxylase Enables Nucleophilic One-Carbon Extension of Aldehydes to Chiral α-Hydroxy Acids
Identification of the 3-amino-3-carboxypropyl (acp) transferase enzyme responsible for acp3U formation at position 47 in Escherichia coli tRNAs
Nucleic Acids Res 2020 Feb 20;48(3):1435-1450
Meyer B, Immer C, Kaiser S, Sharma S, Yang J, Watzinger P, Weiß L, Kotter A, Helm M, Seitz HM, Kötter P, Kellner S, Entian KD, Wöhnert J
Turbidimetry and Dielectric Spectroscopy as Process Analytical Technologies for Mammalian and Insect Cell Cultures
Methods Mol Biol 2020;2095:335-364
Käßer L, Zitzmann J, Grein T, Weidner T, Salzig D, Czermak P
Ion Binding and Selectivity of the Na(+)/H(+) Antiporter MjNhaP1 from Experiment and Simulation
J Phys Chem B 2020 Jan 16;124(2):336-344
Warnau J, Wöhlert D, Okazaki KI, Yildiz Ö, Gamiz-Hernandez AP, Kaila VRI, Kühlbrandt W, Hummer G
Phototemtide A, a Cyclic Lipopeptide Heterologously Expressed from Photorhabdus temperata Meg1, Shows Selective Antiprotozoal Activity
Chembiochem 2020 May 4;21(9):1288-1292
Zhao L, Vo TD, Kaiser M, Bode HB
Type I fatty acid synthase trapped in the octanoyl-bound state
Protein Sci 2020 Feb;29(2):589-605
Rittner A, Paithankar KS, Himmler A, Grininger M
Hierarchical Ensembles of Intrinsically Disordered Proteins at Atomic Resolution in Molecular Dynamics Simulations
J Chem Theory Comput 2020 Jan 14;16(1):725-737
Pietrek LM, Stelzl LS, Hummer G
Crystal structure of the translation recovery factor Trf from Sulfolobus solfataricus
FEBS Open Bio 2019 Dec 5
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Structure, Biosynthesis, and Bioactivity of Photoditritide from Photorhabdus temperata Meg1
J Nat Prod 2019 Dec 27;82(12):3499-3503
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Tangential Flow Filtration for the Concentration of Oncolytic Measles Virus: The Influence of Filter Properties and the Cell Culture Medium
Membranes (Basel) 2019 Nov 29;9(12)
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Nucleic Acids Res 2020 Jan 24;48(2):924-933
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Nucleic Acids Res 2020 Jan 24;48(2):949-961
Duchardt-Ferner E, Juen M, Bourgeois B, Madl T, Kreutz C, Ohlenschläger O, Wöhnert J
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Nat Plants 2019 Dec;5(12):1207-1210
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Nature 2019 Nov;575(7783):500-504
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Development and Characterization of an Enzyme Membrane Reactor for Fructo-Oligosaccharide Production
Membranes (Basel) 2019 Nov 10;9(11)
Burghardt JP, Coletta LA, van der Bolt R, Ebrahimi M, Gerlach D, Czermak P
Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing
Angew Chem Int Ed Engl 2019 Dec 19;58(52):18957-18963
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Selection of High Producers From Combinatorial Libraries for the Production of Recombinant Proteins in Escherichia coli and Vibrio natriegens
Front Bioeng Biotechnol 2019 Oct 4;7:254
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ACS Synth Biol 2019 Nov 15;8(11):2451-2456
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Phospholipid Scramblases Remodel the Shape of Asymmetric Membranes
J Phys Chem Lett 2019 Oct 17;10(20):6351-6354
Siggel M, Bhaskara RM, Hummer G
Structure of the archaeal chemotaxis protein CheY in a domain-swapped dimeric conformation
Acta Crystallogr F Struct Biol Commun 2019 Sep 1;75(Pt 9):576-585
Paithankar KS, Enderle M, Wirthensohn DC, Miller A, Schlesner M, Pfeiffer F, Rittner A, Grininger M, Oesterhelt D
NMR resonance assignments for the GSPII-B domain of the traffic ATPase PilF from Thermus thermophilus in the apo and the c-di-GMP-bound state
Biomol NMR Assign 2019 Oct;13(2):383-390
Neißner K, Keller H, Duchardt-Ferner E, Hacker C, Kruse K, Averhoff B, Wöhnert J
(±)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210 Isolated from the Halophyte Salicornia sp
J Org Chem 2019 Sep 6;84(17):11203-11209
Shi YN, Pusch S, Shi YM, Richter C, Maciá-Vicente JG, Schwalbe H, Kaiser M, Opatz T, Bode HB
Production of a photohexapeptide library from entomopathogenic Photorhabdus asymbiotica PB68
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Inferring Structural Ensembles of Flexible and Dynamic Macromolecules Using Bayesian, Maximum Entropy, and Minimal-Ensemble Refinement Methods
Methods Mol Biol 2019;2022:341-352
Köfinger J, Różycki B, Hummer G
Forced Degradation Studies to Identify Critical Process Parameters for the Purification of Infectious Measles Virus
Viruses 2019 Aug 7;11(8)
Loewe D, Häussler J, Grein TA, Dieken H, Weidner T, Salzig D, Czermak P
NMR resonance assignments for the GSPII-C domain of the PilF ATPase from Thermus thermophilus in complex with c-di-GMP
Biomol NMR Assign 2019 Oct;13(2):361-366
Keller H, Kruse K, Averhoff B, Duchardt-Ferner E, Wöhnert J
Ultrafast Oxidation of a Tyrosine by Proton-Coupled Electron Transfer Promotes Light Activation of an Animal-like Cryptochrome
J Am Chem Soc 2019 Aug 28;141(34):13394-13409
Lacombat F, Espagne A, Dozova N, Plaza P, Müller P, Brettel K, Franz-Badur S, Essen LO
Molecular mechanism of polyketide shortening in anthraquinone biosynthesis of Photorhabdus luminescens
Chem Sci 2019 May 14;10(25):6341-6349
Zhou Q, Bräuer A, Adihou H, Schmalhofer M, Saura P, Grammbitter GLC, Kaila VRI, Groll M, Bode HB
Comparative biochemical and structural analysis of the flavin-binding dodecins from Streptomyces davaonensis and Streptomyces coelicolor reveals striking differences with regard to multimerization
Microbiology 2019 Oct;165(10):1095-1106
Bourdeaux F, Ludwig P, Paithankar K, Sander B, Essen LO, Grininger M, Mack M
Process Intensification for an Insect Antimicrobial Peptide Elastin-Like Polypeptide Fusion Produced in Redox-Engineered Escherichia coli
Front Bioeng Biotechnol 2019 Jun 27;7:150
Joachim M, Maguire N, Schäfer J, Gerlach D, Czermak P
Cryo-EM structure of Neurospora crassa respiratory complex IV
IUCrJ 2019 Jun 26;6(Pt 4):773-780
Bausewein T, Nussberger S, Kühlbrandt W
Improving isobutanol production with the yeast Saccharomyces cerevisiae by successively blocking competing metabolic pathways as well as ethanol and glycerol formation
Biotechnol Biofuels 2019 Jul 2;12:173
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Structural changes within the bifunctional cryptochrome/photolyase CraCRY upon blue light excitation
Sci Rep 2019 Jul 9;9(1):9896
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Dynamic Metabolic Rewiring Enables Efficient Acetyl Coenzyme A Assimilation in Paracoccus denitrificans
mBio 2019 Jul 9;10(4)
Kremer K, van Teeseling MCF, Schada von Borzyskowski L, Bernhardsgrütter I, van Spanning RJM, Gates AJ, Remus-Emsermann MNP, Thanbichler M, Erb TJ
Four amino acids define the CO(2) binding pocket of enoyl-CoA carboxylases/reductases
Proc Natl Acad Sci U S A 2019 Jul 9;116(28):13964-13969
Stoffel GMM, Saez DA, DeMirci H, Vögeli B, Rao Y, Zarzycki J, Yoshikuni Y, Wakatsuki S, Vöhringer-Martinez E, Erb TJ
Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F(1)-F(o) coupling
Science 2019 Jun 21;364(6446)
Murphy BJ, Klusch N, Langer J, Mills DJ, Yildiz Ö, Kühlbrandt W
Membrane perforation by the pore-forming toxin pneumolysin
Proc Natl Acad Sci U S A 2019 Jul 2;116(27):13352-13357
Vögele M, Bhaskara RM, Mulvihill E, van Pee K, Yildiz Ö, Kühlbrandt W, Müller DJ, Hummer G
De novo production of aromatic m-cresol in Saccharomyces cerevisiae mediated by heterologous polyketide synthases combined with a 6-methylsalicylic acid decarboxylase
Awakening the Sleeping Carboxylase Function of Enzymes: Engineering the Natural CO(2)-Binding Potential of Reductases
J Am Chem Soc 2019 Jun 26;141(25):9778-9782
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Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains
Nat Chem 2019 Jul;11(7):653-661
Bozhüyük KAJ, Linck A, Tietze A, Kranz J, Wesche F, Nowak S, Fleischhacker F, Shi YN, Grün P, Bode HB
Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy
Nat Commun 2019 May 30;10(1):2370
Bhaskara RM, Grumati P, Garcia-Pardo J, Kalayil S, Covarrubias-Pinto A, Chen W, Kudryashev M, Dikic I, Hummer G
Finite-Size-Corrected Rotational Diffusion Coefficients of Membrane Proteins and Carbon Nanotubes from Molecular Dynamics Simulations
J Phys Chem B 2019 Jun 20;123(24):5099-5106
Vögele M, Köfinger J, Hummer G
Cyclo(tetrahydroxybutyrate) production is sufficient to distinguish between Xenorhabdus and Photorhabdus isolates in Thailand
Environ Microbiol 2019 Aug;21(8):2921-2932
Tobias NJ, Parra-Rojas C, Shi YN, Shi YM, Simonyi S, Thanwisai A, Vitta A, Chantratita N, Hernandez-Vargas EA, Bode HB
Heterogeneity in Bacterial Specialized Metabolism
(1)H, (13)C, (15)N backbone NMR resonance assignments for the rRNA methyltransferase Dim1 from the hyperthermophilic archaeon Pyrococcus horikoshii
Biomol NMR Assign 2019 Oct;13(2):309-314
Kaiser M, Hacker C, Duchardt-Ferner E, Wöhnert J
Aeration and Shear Stress Are Critical Process Parameters for the Production of Oncolytic Measles Virus
Front Bioeng Biotechnol 2019 Apr 17;7:78
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Dynamic cluster formation determines viscosity and diffusion in dense protein solutions
Proc Natl Acad Sci U S A 2019 May 14;116(20):9843-9852
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NMR resonance assignments for the GTP-binding RNA aptamer 9-12 in complex with GTP
Biomol NMR Assign 2019 Oct;13(2):281-286
Wolter AC, Pianu A, Kremser J, Strebitzer E, Schnieders R, Fürtig B, Kreutz C, Duchardt-Ferner E, Wöhnert J
Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting
Nat Commun 2019 Apr 15;10(1):1742
Okazaki KI, Wöhlert D, Warnau J, Jung H, Yildiz Ö, Kühlbrandt W, Hummer G
Efficient Ensemble Refinement by Reweighting
J Chem Theory Comput 2019 May 14;15(5):3390-3401
Köfinger J, Stelzl LS, Reuter K, Allande C, Reichel K, Hummer G
Protein denaturation at the air-water interface and how to prevent it
Elife 2019 Apr 1;8
D'Imprima E, Floris D, Joppe M, Sánchez R, Grininger M, Kühlbrandt W
Recovery of Lignosulfonates from Spent Sulfite Liquor Using Ceramic Hollow-Fiber Membranes
Membranes (Basel) 2019 Mar 28;9(4)
Humpert D, Ebrahimi M, Stroh A, Czermak P
Fatty Acid Biosynthesis: Chain-Length Regulation and Control
Chembiochem 2019 Sep 16;20(18):2298-2321
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An Uncommon Type II PKS Catalyzes Biosynthesis of Aryl Polyene Pigments
J Am Chem Soc 2019 Oct 23;141(42):16615-16623
Grammbitter GLC, Schmalhofer M, Karimi K, Shi YM, Schöner TA, Tobias NJ, Morgner N, Groll M, Bode HB
Structure and Mechanisms of F-Type ATP Synthases
Dual phenazine gene clusters enable diversification during biosynthesis
Nat Chem Biol 2019 Apr;15(4):331-339
Shi YM, Brachmann AO, Westphalen MA, Neubacher N, Tobias NJ, Bode HB
Back to the future: Why we need enzymology to build a synthetic metabolism of the future
Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila
Beilstein J Org Chem 2019 Feb 25;15:535-541
Wesche F, Adihou H, Wichelhaus TA, Bode HB
Reprogramming Promiscuous Nonribosomal Peptide Synthetases for Production of Specific Peptides
Org Lett 2019 Apr 5;21(7):2116-2120
Cai X, Zhao L, Bode HB
Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows
Proc Natl Acad Sci U S A 2019 Mar 5;116(10):4250-4255
Blum TB, Hahn A, Meier T, Davies KM, Kühlbrandt W
Respiratory supercomplexes III(2)IV(2) come into focus
Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains
ACS Chem Biol 2019 Mar 15;14(3):426-433
Klaus M, D'Souza AD, Nivina A, Khosla C, Grininger M
The structure of the SAM/SAH-binding riboswitch
Nucleic Acids Res 2019 Mar 18;47(5):2654-2665
Weickhmann AK, Keller H, Wurm JP, Strebitzer E, Juen MA, Kremser J, Weinberg Z, Kreutz C, Duchardt-Ferner E, Wöhnert J
Downstream processing of Cry4AaCter-induced inclusion bodies containing insect-derived antimicrobial peptides produced in Escherichia coli
Protein Expr Purif 2019 Mar;155:120-129
Hoffmann D, Eckhardt D, Gerlach D, Vilcinskas A, Czermak P
Editorial overview: Novel enzymes, coenzymes, and metabolic pathways
Native mass spectrometry goes more native: investigation of membrane protein complexes directly from SMALPs
Chem Commun (Camb) 2018 Dec 4;54(97):13702-13705
Hellwig N, Peetz O, Ahdash Z, Tascón I, Booth PJ, Mikusevic V, Diskowski M, Politis A, Hellmich Y, Hänelt I, Reading E, Morgner N
Structural and Functional Characterization of PA14/Flo5-Like Adhesins From Komagataella pastoris
Front Microbiol 2018 Oct 30;9:2581
Kock M, Brückner S, Wozniak N, Maestre-Reyna M, Veelders M, Schlereth J, Mösch HU, Essen LO
Probing the modularity of megasynthases by rational engineering of a fatty acid synthase Type I
Protein Sci 2019 Feb;28(2):414-428
Rittner A, Paithankar KS, Drexler DJ, Himmler A, Grininger M
The multicatalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite
Nat Chem Biol 2018 Dec;14(12):1127-1132
Bernhardsgrütter I, Vögeli B, Wagner T, Peter DM, Cortina NS, Kahnt J, Bange G, Engilberge S, Girard E, Riobé F, Maury O, Shima S, Zarzycki J, Erb TJ
Bacterial bifunctional chorismate mutase-prephenate dehydratase PheA increases flux into the yeast phenylalanine pathway and improves mandelic acid production
Metab Eng Commun 2018 Sep 22;7:e00079
Reifenrath M, Bauer M, Oreb M, Boles E
Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS
Nat Commun 2018 Oct 19;9(1):4366
Hacker C, Cai X, Kegler C, Zhao L, Weickhmann AK, Wurm JP, Bode HB, Wöhnert J
Methionine-Containing Rhabdopeptide/Xenortide-like Peptides from Heterologous Expression of the Biosynthetic Gene Cluster kj12ABC in Escherichia coli
J Nat Prod 2018 Oct 26;81(10):2292-2295
Zhao L, Cai X, Kaiser M, Bode HB
Site-Specific Labelling of Multidomain Proteins by Amber Codon Suppression
Sci Rep 2018 Oct 5;8(1):14864
Heil CS, Rittner A, Goebel B, Beyer D, Grininger M
Dispersion Correction Alleviates Dye Stacking of Single-Stranded DNA and RNA in Simulations of Single-Molecule Fluorescence Experiments
J Phys Chem B 2018 Dec 13;122(49):11626-11639
Grotz KK, Nueesch MF, Holmstrom ED, Heinz M, Stelzl LS, Schuler B, Hummer G
Delocalized hole transport coupled to sub-ns tryptophanyl deprotonation promotes photoreduction of class II photolyases
Phys Chem Chem Phys 2018 Oct 10;20(39):25446-25457
Lacombat F, Espagne A, Dozova N, Plaza P, Ignatz E, Kiontke S, Essen LO
'Negative' and 'positive catalysis': complementary principles that shape the catalytic landscape of enzymes
Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs)
Chem Commun (Camb) 2018 Oct 11;54(82):11606-11609
Rossini E, Gajewski J, Klaus M, Hummer G, Grininger M
LILBID and nESI: Different Native Mass Spectrometry Techniques as Tools in Structural Biology
J Am Soc Mass Spectrom 2019 Jan;30(1):181-191
Peetz O, Hellwig N, Henrich E, Mezhyrova J, Dötsch V, Bernhard F, Morgner N
InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis
J Biol Chem 2018 Nov 2;293(44):17200-17207
Vögeli B, Rosenthal RG, Stoffel GMM, Wagner T, Kiefer P, Cortina NS, Shima S, Erb TJ
Precision DEER Distances from Spin-Label Ensemble Refinement
J Phys Chem Lett 2018 Oct 4;9(19):5748-5752
Reichel K, Stelzl LS, Köfinger J, Hummer G
A superfolder variant of pH-sensitive pHluorin for in vivo pH measurements in the endoplasmic reticulum
Sci Rep 2018 Aug 10;8(1):11985
Reifenrath M, Boles E
Rhabdopeptide/Xenortide-like Peptides from Xenorhabdus innexi with Terminal Amines Showing Potent Antiprotozoal Activity
Org Lett 2018 Sep 7;20(17):5116-5120
Zhao L, Kaiser M, Bode HB
NMR resonance assignments for the SAM/SAH-binding riboswitch RNA bound to S-adenosylhomocysteine
Biomol NMR Assign 2018 Oct;12(2):329-334
Weickhmann AK, Keller H, Duchardt-Ferner E, Strebitzer E, Juen MA, Kremser J, Wurm JP, Kreutz C, Wöhnert J
Bayesian inference of rotor ring stoichiometry from electron microscopy images of archaeal ATP synthase
Microscopy (Oxf) 2018 Oct 1;67(5):266-273
Cossio P, Allegretti M, Mayer F, Müller V, Vonck J, Hummer G
Structure of the bifunctional cryptochrome aCRY from Chlamydomonas reinhardtii
Nucleic Acids Res 2018 Sep 6;46(15):8010-8022
Franz S, Ignatz E, Wenzel S, Zielosko H, Putu EPGN, Maestre-Reyna M, Tsai MD, Yamamoto J, Mittag M, Essen LO
Adenine protonation enables cyclic-di-GMP binding to cyclic-GAMP sensing riboswitches
RNA 2018 Oct;24(10):1390-1402
Keller H, Weickhmann AK, Bock T, Wöhnert J
Hydrodynamics of Diffusion in Lipid Membrane Simulations
Phys Rev Lett 2018 Jun 29;120(26):268104
Vögele M, Köfinger J, Hummer G
Single-cell cloning enables the selection of more productive Drosophila melanogaster S2 cells for recombinant protein expression
Biotechnol Rep (Amst) 2018 Jul 3;19:e00272
Zitzmann J, Schreiber C, Eichmann J, Bilz RO, Salzig D, Weidner T, Czermak P
Molecular dynamics simulations of carbon nanotube porins in lipid bilayers
Faraday Discuss 2018 Sep 28;209(0):341-358
Vögele M, Köfinger J, Hummer G
Engineering strategies for rational polyketide synthase design
NMR resonance assignments for a ProQ homolog from Legionella pneumophila
Biomol NMR Assign 2018 Oct;12(2):319-322
Immer C, Hacker C, Wöhnert J
An engineered fatty acid synthase combined with a carboxylic acid reductase enables de novo production of 1-octanol in Saccharomyces cerevisiae
Biotechnol Biofuels 2018 Jun 1;11:150
Henritzi S, Fischer M, Grininger M, Oreb M, Boles E
Characterization of the small flavin-binding dodecin in the roseoflavin producer Streptomyces davawensis
Microbiology 2018 Jun;164(6):908-919
Ludwig P, Sévin DC, Busche T, Kalinowski J, Bourdeaux F, Grininger M, Mack M
Refining the Natural Product Repertoire in Entomopathogenic Bacteria
Trends Microbiol 2018 Oct;26(10):833-840
Tobias NJ, Shi YM, Bode HB
Rotational Diffusion Depends on Box Size in Molecular Dynamics Simulations
J Phys Chem Lett 2018 Jun 7;9(11):2874-2878
Linke M, Köfinger J, Hummer G
Structure, mechanism, and regulation of the chloroplast ATP synthase
Science 2018 May 11;360(6389)
Hahn A, Vonck J, Mills DJ, Meier T, Kühlbrandt W
Combining Promiscuous Acyl-CoA Oxidase and Enoyl-CoA Carboxylase/Reductases for Atypical Polyketide Extender Unit Biosynthesis
Cell Chem Biol 2018 Jul 19;25(7):833-839
Vögeli B, Geyer K, Gerlinger PD, Benkstein S, Cortina NS, Erb TJ
Sub-nanosecond tryptophan radical deprotonation mediated by a protein-bound water cluster in class II DNA photolyases
Chem Sci 2017 Dec 11;9(5):1200-1212
Müller P, Ignatz E, Kiontke S, Brettel K, Essen LO
Combined Approach of Backbone Amide Linking and On-Resin N-Methylation for the Synthesis of Bioactive and Metabolically Stable Peptides
J Med Chem 2018 May 10;61(9):3930-3938
Wesche F, Adihou H, Kaiser A, Wurglics M, Schubert-Zsilavecz M, Kaiser M, Bode HB
An engineered Calvin-Benson-Bassham cycle for carbon dioxide fixation in Methylobacterium extorquens AM1
Metab Eng 2018 May;47:423-433
Schada von Borzyskowski L, Carrillo M, Leupold S, Glatter T, Kiefer P, Weishaupt R, Heinemann M, Erb TJ
Flavin Storage and Sequestration by Mycobacterium tuberculosis Dodecin
ACS Infect Dis 2018 Jul 13;4(7):1082-1092
Bourdeaux F, Hammer CA, Vogt S, Schweighöfer F, Nöll G, Wachtveitl J, Grininger M
The benzodiazepine-like natural product tilivalline is produced by the entomopathogenic bacterium Xenorhabdus eapokensis
Likelihood-based structural analysis of electron microscopy images
Dielectric Spectroscopy and Optical Density Measurement for the Online Monitoring and Control of Recombinant Protein Production in Stably Transformed Drosophila melanogaster S2 Cells
Sensors (Basel) 2018 Mar 18;18(3)
Zitzmann J, Weidner T, Eichner G, Salzig D, Czermak P
Retinal isomerization and water-pore formation in channelrhodopsin-2
Structure of the catalytic F(1) head of the F(1)-F(o) ATP synthase from Trypanosoma brucei
Conserved in situ arrangement of complex I and III(2) in mitochondrial respiratory chain supercomplexes of mammals, yeast, and plants
Natural Product Diversification Mediated by Alternative Transcriptional Starting
Georatusin, a Specific Antiparasitic Polyketide-Peptide Hybrid from the Fungus Geomyces auratus
Org Lett 2018 Mar 16;20(6):1563-1567
Shi YM, Richter C, Challinor VL, Grün P, Girela Del Rio A, Kaiser M, Schüffler A, Piepenbring M, Schwalbe H, Bode HB
Cryo-electron tomography analyses of terminal organelle mutants suggest the motility mechanism of Mycoplasma genitalium
Mol Microbiol 2018 May;108(3):319-329
Seybert A, Gonzalez-Gonzalez L, Scheffer MP, Lluch-Senar M, Mariscal AM, Querol E, Matthaeus F, Piñol J, Frangakis AS
Mitochondrial Respiratory Chain Complexes
Subcell Biochem 2018;87:167-227
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De novo design and engineering of non-ribosomal peptide synthetases
Nat Chem 2018 Mar;10(3):275-281
Bozhüyük KAJ, Fleischhacker F, Linck A, Wesche F, Tietze A, Niesert CP, Bode HB
Metabolomics-based chemotaxonomy of root endophytic fungi for natural products discovery
Environ Microbiol 2018 Mar;20(3):1253-1270
Maciá-Vicente JG, Shi YN, Cheikh-Ali Z, Grün P, Glynou K, Kia SH, Piepenbring M, Bode HB
Fully Anisotropic Rotational Diffusion Tensor from Molecular Dynamics Simulations
J Phys Chem B 2018 May 31;122(21):5630-5639
Linke M, Köfinger J, Hummer G
Chemical language and warfare of bacterial natural products in bacteria-nematode-insect interactions
Engineering of hydroxymandelate synthases and the aromatic amino acid pathway enables de novo biosynthesis of mandelic and 4-hydroxymandelic acid with Saccharomyces cerevisiae
Metab Eng 2018 Jan;45:246-254
Reifenrath M, Boles E
Characterization of the Polyspecific Transferase of Murine Type I Fatty Acid Synthase (FAS) and Implications for Polyketide Synthase (PKS) Engineering
ACS Chem Biol 2018 Mar 16;13(3):723-732
Rittner A, Paithankar KS, Huu KV, Grininger M
High titer oncolytic measles virus production process by integration of dielectric spectroscopy as online monitoring system
Biotechnol Bioeng 2018 May;115(5):1186-1194
Grein TA, Loewe D, Dieken H, Salzig D, Weidner T, Czermak P
Molecular Basis for Converting (2S)-Methylsuccinyl-CoA Dehydrogenase into an Oxidase
Molecules 2017 Dec 28;23(1)
Burgener S, Schwander T, Romero E, Fraaije MW, Erb TJ
Structural basis for substrate specificity of methylsuccinyl-CoA dehydrogenase, an unusual member of the acyl-CoA dehydrogenase family
J Biol Chem 2018 Feb 2;293(5):1702-1712
Schwander T, McLean R, Zarzycki J, Erb TJ
Structural basis of proton translocation and force generation in mitochondrial ATP synthase
Elife 2017 Dec 6;6
Klusch N, Murphy BJ, Mills DJ, Yildiz Ö, Kühlbrandt W
Optimisation of trans-cinnamic acid and hydrocinnamyl alcohol production with recombinant Saccharomyces cerevisiae and identification of cinnamyl methyl ketone as a by-product
FEMS Yeast Res 2017 Dec 1;17(8)
Gottardi M, Grün P, Bode HB, Hoffmann T, Schwab W, Oreb M, Boles E
Reassessment of inclusion body-based production as a versatile opportunity for difficult-to-express recombinant proteins
Crit Rev Biotechnol 2018 Aug;38(5):729-744
Hoffmann D, Ebrahimi M, Gerlach D, Salzig D, Czermak P
Classical Molecular Dynamics with Mobile Protons
Scaffolding the cup-shaped double membrane in autophagy
PLoS Comput Biol 2017 Oct 24;13(10):e1005817
Bahrami AH, Lin MG, Ren X, Hurley JH, Hummer G
Dynamic Histogram Analysis To Determine Free Energies and Rates from Biased Simulations
J Chem Theory Comput 2017 Dec 12;13(12):6328-6342
Stelzl LS, Kells A, Rosta E, Hummer G
Transition path sampling of rare events by shooting from the top
J Chem Phys 2017 Oct 21;147(15):152716
Jung H, Okazaki KI, Hummer G
Insights into Cotranslational Membrane Protein Insertion by Combined LILBID-Mass Spectrometry and NMR Spectroscopy
Anal Chem 2017 Nov 21;89(22):12314-12318
Peetz O, Henrich E, Laguerre A, Löhr F, Hein C, Dötsch V, Bernhard F, Morgner N
NMR experiments for the rapid identification of P=O···H-X type hydrogen bonds in nucleic acids
J Biomol NMR 2017 Oct;69(2):101-110
Duchardt-Ferner E, Wöhnert J
Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus
Nat Microbiol 2017 Dec;2(12):1676-1685
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Environ Microbiol 2017 Nov;19(11):4564-4575
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Open Biomed Eng J 2017 Jul 31;11:72-84
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Nicotinamide Adenine Dinucleotides Arrest Photoreduction of Class II DNA Photolyases in FADH(˙) State
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N Biotechnol 2017 Oct 25;39(Pt B):161-166
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The components of shear stress affecting insect cells used with the baculovirus expression vector system
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Cryo-EM Structure of the TOM Core Complex from Neurospora crassa
Cell 2017 Aug 10;170(4):693-700
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Resolving the Conformational Dynamics of DNA with Ångstrom Resolution by Pulsed Electron-Electron Double Resonance and Molecular Dynamics
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Strategies in megasynthase engineering - fatty acid synthases (FAS) as model proteins
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PeerJ 2017 Jun 26;5:e3471
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Environ Microbiol 2017 Oct;19(10):4080-4090
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Structure and in situ organisation of the Pyrococcus furiosus archaellum machinery
Elife 2017 Jun 27;6
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Secretion of 2,3-dihydroxyisovalerate as a limiting factor for isobutanol production in Saccharomyces cerevisiae
FEMS Yeast Res 2017 May 1;17(3)
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A conserved threonine prevents self-intoxication of enoyl-thioester reductases
Nat Chem Biol 2017 Jul;13(7):745-749
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Position-Dependent Diffusion Tensors in Anisotropic Media from Simulation: Oxygen Transport in and through Membranes
J Chem Theory Comput 2017 Jun 13;13(6):2962-2976
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Microbiology: A new language for small talk
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De novo biosynthesis of trans-cinnamic acid derivatives in Saccharomyces cerevisiae
Appl Microbiol Biotechnol 2017 Jun;101(12):4883-4893
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Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design
Nat Chem 2017 Apr;9(4):379-386
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Engineering fungal de novo fatty acid synthesis for short chain fatty acid production
Nat Commun 2017 Mar 10;8:14650
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The Global Regulators Lrp, LeuO, and HexA Control Secondary Metabolism in Entomopathogenic Bacteria
Front Microbiol 2017 Feb 17;8:209
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Engineering fatty acid synthases for directed polyketide production
Nat Chem Biol 2017 Apr;13(4):363-365
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Expanding the product portfolio of fungal type I fatty acid synthases
Nat Chem Biol 2017 Apr;13(4):360-362
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A high-throughput expression screening platform to optimize the production of antimicrobial peptides
Microb Cell Fact 2017 Feb 13;16(1):29
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Biosynthesis of the Antibiotic Nematophin and Its Elongated Derivatives in Entomopathogenic Bacteria
Org Lett 2017 Feb 17;19(4):806-809
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Optimized expression of the antimicrobial protein Gloverin from Galleria mellonella using stably transformed Drosophila melanogaster S2 cells
Cytotechnology 2017 Apr;69(2):371-389
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Carbon Nanotubes Mediate Fusion of Lipid Vesicles
ACS Nano 2017 Feb 28;11(2):1273-1280
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Natural Products from Photorhabdus and Other Entomopathogenic Bacteria
Curr Top Microbiol Immunol 2017;402:55-79
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Analyzing native membrane protein assembly in nanodiscs by combined non-covalent mass spectrometry and synthetic biology
Elife 2017 Jan 9;6
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Screening different host cell lines for the dynamic production of measles virus
Biotechnol Prog 2017 Jul;33(4):989-997
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A Stably Protonated Adenine Nucleotide with a Highly Shifted pK(a) Value Stabilizes the Tertiary Structure of a GTP-Binding RNA Aptamer
Angew Chem Int Ed Engl 2017 Jan 2;56(1):401-404
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NMR resonance assignments for the tetramethylrhodamine binding RNA aptamer 3 in complex with the ligand 5-carboxy-tetramethylrhodamine
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Photorhabdus-nematode symbiosis is dependent on hfq-mediated regulation of secondary metabolites
Environ Microbiol 2017 Jan;19(1):119-129
Tobias NJ, Heinrich AK, Eresmann H, Wright PR, Neubacher N, Backofen R, Bode HB
Three-dimensional CTF correction improves the resolution of electron tomograms